US2008275125A1PendingUtilityA1

Combination Composition

60
Assignee: AFT PHARMACEUTICALS LTDPriority: Jul 7, 2004Filed: Jul 7, 2005Published: Nov 6, 2008
Est. expiryJul 7, 2024(expired)· nominal 20-yr term from priority
Inventors:Hartley Campbell Atkinson
A61K 31/215A61K 31/16A61P 29/00A61K 9/2059A61P 25/04A61K 31/167A61K 31/192A61K 31/44A61K 31/216A61K 31/165A61K 31/19
60
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Claims

Abstract

A combination pharmaceutical composition for the treatment of pain including about 125 mg to about 150 mg ibuprofen and about 475 mg to about 500 mg paracetamol.

Claims

exact text as granted — not AI-modified
1 - 26 . (canceled) 
     
     
         27 . A combination pharmaceutical composition for the treatment of pain including about 125 mg to about 150 mg ibuprofen and about 475 mg to about 500 mg paracetamol. 
     
     
         28 . The combination composition according to  claim 27  wherein the ratio of paracetamol:ibuprofen is about 50:15. 
     
     
         29 . The combination composition according to  claim 27  wherein the composition includes 150 mg ibuprofen and 500 mg paracetamol. 
     
     
         30 . The combination composition according to  claim 27  wherein the ibuprofen is present as a salt, ester or complexed form in an amount suitable to deliver between about 125 mg to about 150 mg ibuprofen. 
     
     
         31 . The combination composition according to  claim 27  wherein the composition is suitable to be administered as two unit doses four times a day. 
     
     
         32 . The combination composition according to  claim 27  wherein the composition is suitable to be administered as two unit doses four times a day, and the unit doses are tablets or capsules. 
     
     
         33 . A method of pain management by providing a dosing regime for the delivery of both paracetamol and ibuprofen wherein paracetamol and ibuprofen are administered in a combination composition, including about 125 mg to about 150 mg ibuprofen and about 475 mg to about 500 mg paracetamol per single dose, and wherein the single dose is given in two unit doses four times daily. 
     
     
         34 . The method of pain management according to  claim 33  wherein the unit doses are tablets or capsules. 
     
     
         35 . The method of pain management according to  claim 33  wherein the ratio of paracetamol:ibuprofen in the single therapeutic dose is about 50:15. 
     
     
         36 . The method of pain management according to  claim 33  wherein the ibuprofen is present as a salt, ester or complexed form in an amount suitable to deliver between about 125 mg and about 150 mg ibuprofen. 
     
     
         37 . The method of pain management according to  claim 33  wherein the composition includes 150 mg ibuprofen and 500 mg paracetamol. 
     
     
         38 . The use of about 475 mg to about 500 mg paracetamol and about 125 mg to about 150 mg ibuprofen in the manufacture of a medicament to be administered in two unit doses four times a day for the treatment of pain. 
     
     
         39 . The use according to  claim 38  wherein the ratio of paracetamol:ibuprofen is about 50:15. 
     
     
         40 . The use according to  claim 38  wherein the ibuprofen is present as a salt, ester or complexed form in an amount suitable to deliver between about 125 mg and about 150 mg ibuprofen. 
     
     
         41 . The use according to  claim 38  wherein 150 mg ibuprofen and 500 mg paracetamol is used. 
     
     
         42 . A pharmaceutical pack including tablets or capsules, each tablet or capsule including a pharmaceutical composition according to  claim 27 , the pack including instructions to a user to take two tablets or capsules no more than 4 times a day. 
     
     
         43 . A pharmaceutical pack including tablets or capsules, each tablet or capsule including pharmaceutical composition according to  claim 27 , the pack including instructions to a user to take two tablets or capsules no more than 4 times a day, wherein the pharmaceutical pack includes an even number of tablets or capsules. 
     
     
         44 . A pharmaceutical pack including tablets or capsules, each tablet or capsule including pharmaceutical composition according to  claim 27 , the pack including instructions to a user to take two tablets or capsules no more than 4 times a day, wherein the pack includes at least 8 tablets or capsules. 
     
     
         45 . A pharmaceutical composition for the treatment of pain, the composition including paracetamol and ibuprofen in a synergistically effective ratio range of between about 42.5:12.5 to about 50:15. 
     
     
         46 . The pharmaceutical composition according to  claim 45  wherein the ratio is 50:15. 
     
     
         47 . The pharmaceutical composition according to  claim 45  wherein the composition includes a salt, ester or complexed form of ibuprofen in an amount sufficient to deliver ibuprofen to the user within the stated ratio range. 
     
     
         48 . The pharmaceutical composition according to  claim 45  wherein the composition includes a salt, ester or complexed form of ibuprofen in an amount sufficient to deliver ibuprofen to the user within the stated ratio range, and wherein the composition is a tablet or capsule. 
     
     
         49 . The pharmaceutical composition according to  claim 45  wherein the composition is administered four times a day. 
     
     
         50 . A method of pain management including providing about 250 mg to about 300 mg ibuprofen and about 975 mg to about 1000 mg paracetamol in a single administration. 
     
     
         51 . The method of  claim 50  wherein the ibuprofen and paracetamol are administered four times a day. 
     
     
         52 . The method of  claim 50  wherein the ibuprofen and paracetamol are delivered in two unit doses per single administration.

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