Treatment protocol generation for diseases related to angiogenesis

Abstract

A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors. Effective vessel density (EVD) is incorporated as a factor regulating switching on and switching off of at least one component in the angiogenesis model. Effects of vasculature maturation and mature vessels destabilization are incorporated. Pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue are selected. Effects of drugs in the pro-angiogenesis and anti-angiogenesis factors are incorporated. A plurality of treatment protocols in a protocol space is generated. A best treatment protocol based on a pre-determined criteria.

1 . A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising:
 creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;   incorporating effects of vasculature maturation and mature vessels destabilization;   selecting pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue;   incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors; generating a plurality of treatment protocols in a protocol space; and   selecting a best treatment protocol based on a pre-determined criteria.   
   
   
       2 . A system for determining an optimal treatment protocol for a disease related to angiogenesis, comprising:
 an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;   a treatment protocol space generator that generates a protocol space of possible treatments for the disease;   a treatment selector that selects an optimal protocol,   wherein the model incorporates effects of vasculature maturation and mature vessels destabilization;   wherein the system is adapted to effect selection of pro-angiogenesis and anti-angiogenesis factors which can influence changes in state of a tissue and incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors.   
   
   
       3 . A computer program product, including computer-readable media comprising instructions to implement procedures for determining an optimal treatment protocol for a disease related to angiogenesis, said procedure comprising:
 creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;   incorporating effects of vasculature maturation and mature vessels destabilization;   selecting pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue;   incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors;   generating a plurality of treatment protocols space; and   selecting a best treatment protocol based on a pre-determined criteria.