Physiologically balanced, ionized, acidic solution and methodology for use in wound healing

Abstract

Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride. A typical electrolyzed solution of the present invention has a pH within the range of about 2 to about 5, an oxidation reduction potential within the range of about +600 mV to about +1200 mV, and hypohalous acid concentration in the range of about 10 ppm to about 200 ppm. The solution has bactericidal, fungicidal, and sporicidal properties. The composition of the invention is nontoxic and has antibacterial properties, and is useful in any application in which antimicrobial properties are desirable.

1 - 36 . (canceled) 
     
     
         37 . A method for the treatment of a medical condition selected from the groups consisting of disinfection or decontamination of open wounds and burns, promotion of wound healing, in a patient in need of such treatment comprising: applying to a treatment site an effective amount of a stable aqueous physiologically balanced, ionized solution comprising an acidic solution of hypohalous acid with a concentration from about 0.1 ppm to about 1,000 ppm; a halide comprising salt, the halide comprising salt is sodium chloride at a concentration of about four-tenth to slightly higher than full strength of normal or isotonic saline solution, said solution having a pH range from about 3.0 to about 4.0, an original reduction potential (ORP) at room temperature ranging from about +600 mV to about +1200 mV, and said ORP ranging from no less than about 90 to 97.5% of the original ORP after three months at room temperature; and said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. 
     
     
         38 . A method for the treatment of a medical condition selected from the groups consisting of disinfection, decontamination of open wounds and promotion of wound healing in a patient in need of such treatment comprising: applying to a treatment site an effective amount of a stable aqueous physiologically balanced, ionized solution comprising an acidic solution of hypohalous acid with a concentration from about 1 ppm to about 750 ppm; a halide comprising salt, the halide comprising salt is sodium chloride at a concentration of about four-tenth to slightly higher than full strength of normal or isotonic saline solution, said solution having a pH range from about 3.0 to about 4.0, an original reduction potential (ORP) at room temperature ranging from about +600 mV to about +1200 mV, and said ORP ranging from no less than about 90 to 97.5% of the original ORP after three months at room temperature; and said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. 
     
     
         39 . A method of disinfecting or decontaminating open wounds and promoting wound healing by treating a patient in need thereof with an effective amount of a stable aqueous physiologically balanced, ionized solution comprising an acidic solution of hypohalous acid with a concentration from about 5 ppm to about 500 ppm; a halide comprising salt, the halide comprising salt is sodium chloride at a concentration of about four-tenth to slightly higher than full strength of normal or isotonic saline solution, said solution having a pH range from about 3.0 to about 4.0, an original reduction potential (ORP) at room temperature ranging from about +600 mV to about +1200 mV, and said ORP ranging from no less than about 90 to 97.5% of the original ORP after three months at room temperature; and said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. 
     
     
         40 . The method of  claim 37  wherein the pH range is from about 3.5 to about 4.0. 
     
     
         41 . The method of  claim 38  wherein the pH range is from about 3.5 to about 4.0. 
     
     
         42 . The method of  claim 39  wherein the pH range is from about 3.5 to about 4.0. 
     
     
         43 . The method of  claim 40  wherein the pH is about 3.5. 
     
     
         44 . The method of  claim 41  wherein the pH is about 3.5. 
     
     
         45 . The method of  claim 42  wherein the pH is about 3.5. 
     
     
         46 . The method of  claim 37  wherein the sodium chloride concentration is from about 4 g/l to about 10 μl. 
     
     
         47 . The method of  claim 38  wherein the sodium chloride concentration is from about 4 g/l to about 10 g/l. 
     
     
         48 . The method of  claim 39  wherein the sodium chloride concentration is from about 4 g/l to about 10 g/l. 
     
     
         49 . The method of  claim 46  wherein the sodium chloride concentration is about 9 g/l. 
     
     
         50 . The method of  claim 47  wherein the sodium chloride concentration is about 9 g/l. 
     
     
         51 . The method of  claim 48  wherein the sodium chloride concentration is about 9 g/l. 
     
     
         52 . The method of  claim 37 , the hypohalous acid is selected from the group consisting of HOBr and HOCl. 
     
     
         53 . The method of  claim 38 , the hypohalous acid is selected from the group consisting of HOBr and HOCl. 
     
     
         54 . The method of  claim 39 , the hypohalous acid is selected from the group consisting of HOBr and HOCl.