Autonomic nervous activity monitor, blood processing apparatus, blood collecting apparatus and autonomic nervous activity monitoring method

Abstract

An autonomic nervous activity monitor capable of predicting occurrence of abnormal reaction depending on autonomic nervous activity and used for medical practice and the like is provided. A blood component collecting apparatus 100 carries out frequency analysis to a pattern of heartbeat which is acquired by an ECG 300 from a donor, and calculates a high frequency component value [msec 2 ] defined as an indicator for parasympathetic activity and a ratio value of a low frequency component to the high frequency component defined as an indicator for sympathetic activity to detect a change in these values on a time-series base. When a judgment circuit 204 predicts that abnormal reaction may occur to a donor after blood collection operation is started, a controller 200 controls a pump 9 to decrease a blood drawing or blood returning speed, or, to stop blood drawing or blood returning operation.

1 . A blood processing apparatus that carries out blood drawing operation for drawing blood from a body and blood returning operation for returning blood to the body, comprising:
 a biological information acquisition unit which measures heartbeat or pulse of a body to acquire a pattern of the heartbeat or pulse as biological information;   a calculation unit which calculates a value [msec 2 ] of a high frequency component (a HF value) defined as an indicator for parasympathetic activity and a value of a ratio of a low frequency component (LF) to the high frequency component (a LF/HF ratio value) defined as an indicator for sympathetic activity on a time-series base by carrying out frequency analysis to the pattern of the heartbeat or pulse acquired by the biological information acquisition unit;   a blood drawing unit which carries out the blood drawing operation to the body;   a blood processing unit which processes blood drawn from the body by the blood drawing unit;   a blood returning unit which returns to the body blood processed by the blood processing unit; and   a controlling unit which controls the blood drawing unit, the blood processing unit and the blood returning unit, and which predicts whether abnormal reaction may occur to the body from a predetermined relationship between the HF value and the LF/HF ratio value, based upon the HF values and the LF/HF ratio values calculated by the calculation unit,   wherein the controlling unit, when predicted that abnormal reaction may occur to the body after starting the blood drawing operation of the blood drawing unit, reduces a rate for drawing blood from the body according to the blood drawing unit or a rate for returning blood to the body according to the blood returning unit, or, stops the blood drawing operation of the blood drawing unit or the blood returning operation of the blood returning unit.   
     
     
         2 . A blood processing apparatus according to  claim 1 , wherein, when alpha is defined as a predetermined coefficient, the controlling unit predicts that abnormal reaction may occur to the body when a sum of a period of {(the HF value calculated by the calculation unit)>(the coefficient alpha)×(the LF/HF ratio value calculated by the calculation unit)} becomes not less than 75% of a calculation period carried out by the calculation unit. 
     
     
         3 . A blood processing apparatus according to  claim 2 , wherein the coefficient alpha ranges from 10 to 100 and the calculation period ranges from 1.25 to 10 [min]. 
     
     
         4 . A blood collecting apparatus that carries out blood collection operation to a body, comprising:
 a biological information acquisition unit which measures heartbeat or pulse of a body to acquire a pattern of the heartbeat or pulse as biological information;   a calculation unit which calculates a value [msec 2 ] of a high frequency component (a HF value) defined as an indicator for parasympathetic activity and a value of a ratio of a low frequency component (LF) to the high frequency component (a LF/HF ratio value) defined as an indicator for sympathetic activity on a time-series base by carrying out frequency analysis to the pattern of the heartbeat or pulse acquired by the biological information acquisition unit;   a blood collection unit which carries out the blood collection operation to the body; and   a controlling unit which controls the blood collection unit and which predicts whether abnormal reaction may occur to the body from a predetermined relationship between the HF value and the LF/HF ratio value, based upon the HF values and the LF/HF ratio values calculated by the calculation unit,   wherein the controlling unit, when predicted that abnormal reaction may occur to the body after starting the blood collection operation of the blood processing unit, reduces a rate for collecting blood from the body according to the blood collection unit, or, stops the collection operation of the blood collection unit.   
     
     
         5 . A blood collecting apparatus according to  claim 4 , wherein, when alpha is defined as a predetermined coefficient, the controlling unit predicts that abnormal reaction may occur to the body when a sum of a period of {(the HF value calculated by the calculation unit)>(the coefficient alpha)×(the LF/HF ratio value calculated by the calculation unit)} becomes not less than 75% of a calculation period carried out by the calculation unit. 
     
     
         6 . A blood collecting apparatus according to  claim 5 , wherein the coefficient alpha ranges from 10 to 100 and the calculation period ranges from 1.25 to 10 [min]. 
     
     
         7 . A blood collecting apparatus according to  claim 4 , further comprising an information unit which, when the controlling unit predicts that abnormal reaction may occur to the body, informs an operator that abnormal reaction may occur.