MRI phantom and MRI system

Abstract

It is intended to provide a Magnetic Resonance Imaging (MRI) phantom for 1 H/ 19 F signal detection that permits the stable and uniform dispersion of a vesicle and to accomplish the adjustment of a measurement parameter for a 1 H/ 19 F signal and performance confirmation by use of the phantom. The present invention provides an MRI phantom having a gel comprising a vesicle comprising at least one of a perfluorocarbon and a superparamagnetic iron oxide particle and an MRI system having the phantom.

1 . An MRI phantom having a gel comprising a vesicle comprising at least one of a perfluorocarbon and a superparamagnetic iron oxide particle. 
   
   
       2 . The MRI phantom according to  claim 1 , wherein the perfluorocarbon is any selected from the group consisting of perfluoro-n-pentane, perfluoro-n-hexane, perfluoro-n-heptane, perfluoro-n-octane, perfluorotributylamine, and perfluoro-15-crown-5-ether. 
   
   
       3 . The MRI phantom according to  claim 1 , wherein the superparamagnetic iron oxide particle is ferric oxide or ammonium iron citrate. 
   
   
       4 . The MRI phantom according to  claim 1 , wherein the shell of the vesicle comprises lipid. 
   
   
       5 . The MRI phantom according to  claim 1 , wherein the gel is an acrylamide gel. 
   
   
       6 . The MRI phantom according to  claim 1 , wherein the MRI phantom has an acrylamide gel comprising a vesicle comprising perfluoro-n-octane and phosphatidylcholine. 
   
   
       7 . The MRI phantom according to  claim 1 , wherein the MRI phantom has an acrylamide gel comprising a vesicle comprising ferric oxide and phosphatidylcholine. 
   
   
       8 . The MRI phantom according to  claim 1 , wherein the MRI has a static magnetic field strength of 1.5 tesla or higher. 
   
   
       9 . The MRI phantom according to  claim 1 , wherein the MRI has a static magnetic field strength of 3.0 tesla or higher. 
   
   
       10 . An MRI system having:
 an MRI phantom having a gel comprising a vesicle comprising at least one of a perfluorocarbon and a superparamagnetic iron oxide particle;   a magnetic field irradiation part for applying a magnetic field to the phantom;   a signal reception part for acquiring a magnetic signal from the phantom;   a memory part for storing information about the magnetic signal; and   a signal processing part for reading out the information from the memory part and performing predetermined signal processing.   
   
   
       11 . The MRI system according to  claim 10 , wherein the perfluorocarbon is any selected from the group consisting of perfluoro-n-pentane, perfluoro-n-hexane, perfluoro-n-heptane, perfluoro-n-octane, perfluorotributylamine, and perfluoro-15-crown-5-ether. 
   
   
       12 . The MRI system according to  claim 10 , wherein the superparamagnetic iron oxide particle is ferric oxide or ammonium iron citrate. 
   
   
       13 . The MRI system according to  claim 10 , wherein the shell of the vesicle comprises lipid. 
   
   
       14 . The MRI system according to  claim 10 , wherein the gel is an acrylamide gel. 
   
   
       15 . The MRI system according to  claim 10 , wherein the MRI system has an acrylamide gel comprising a vesicle comprising perfluoro-n-octane and phosphatidylcholine. 
   
   
       16 . The MRI system according to  claim 10 , wherein the MRI system has an acrylamide gel comprising a vesicle comprising ferric oxide and phosphatidylcholine. 
   
   
       17 . The MRI system according to  claim 10 , wherein the magnetic field irradiation part performs irradiation with a magnetic field at a static magnetic field strength of 1.5 tesla or higher. 
   
   
       18 . The MRI system according to  claim 10 , wherein the magnetic field irradiation part performs irradiation with a magnetic field at a static magnetic field strength of 3.0 tesla or higher. 
   
   
       19 . A method for adjusting a measurement parameter for a  1 H/ 19 F signal in an MRI apparatus by use of an MRI phantom according to  claim 1 . 
   
   
       20 . The method according to  claim 19 , wherein the measurement parameter for a  1 H/ 19 F signal is one or more selected from the strength of applied RF, an echo time, a repetition time, an echo train length, FOV, a matrix size, the number of excitations, a bandwidth, and a slice thickness.