Drugs for treating hypertension combined with hyperuricemia and/or hypercholesterolemia

Abstract

The invention is directed to a drug for treating hypertension combined with serum hyperuricemia and/or hypercholesterolemia, with the active ingredients being 2-propyl-3-{[21-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-5,6,7, 8-tetrahydrocyclohepta imidazole-4-(3H)-one and a prodrug or salt thereof. Pratosartan can be used in combination with one or more diuretics chosen from sulfonamide-, phenoxyacetic acid- and thiazide-type diuretics, triamterene, amiloride, spironolactone, potassium canrenoate and traxanox sodium. Also, pratosartan can be used in combination with one or more hypolipidemic drugs chosen from statins, fibrates, cholesterol absorption inhibitors, cholesterol sequestrants and cholesterol excretion enhancers.

1 . A method of treating a patient having hypertension and at least one of serum hyperuricemia and hypercholesterolemia comprising the step of administering to the patient a pharmaceutically effective amount of 2-propyl-3-{[2′-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-5,6,7, 8-tetrahydrocycloheptaimidazole-4-(3H)-one, or a pharmaceutically acceptable salt thereof. 
   
   
       2 . The method of  claim 1 , wherein a diuretic is co-administered. 
   
   
       3 . The method of  claim 2 , wherein the diuretic is one or more diuretics selected from the group consisting of a sulfonamide, a phenoxyacetic acid, a thiazide, triamterene, amiloride, spironolactone, potassium canrenoate and traxanox sodium. 
   
   
       4 . The method of  claim 2 , wherein the diuretic is one or more thiazides selected from the group consisting of hydrochlorothiazide, methylclothiazide, benzylhydrocholorothiazide, trichloromethiazide, cyclopenthiazide, ethiazide, cyclothiazide, bendroflumethiazide and hydroflumethiazide. 
   
   
       5 . A method of treating a patient having hypertension and hypercholesterolemia comprising the step of administering to the patient a pharmaceutically effective amount of 2-propyl-3-{[2′-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-5,6,7, 8-tetrahydrocycloheptaimidazole-4-one, or a pharmaceutically acceptable salt thereof, and a hypolipidemic drug. 
   
   
       6 . The method of  claim 5 , wherein the hypolipidemic drug is one or more hypolipidemic diuretics selected from the group consisting of a statin, a fibrate, a cholesterol absorption inhibitor, a cholesterol sequestrant and a cholesterol excretion enhancer.