Use of extracts of the genus cimicifuga as organoselective medicines for treating diseases of the genitourinary tract caused by sex hormones

Abstract

The present invention relates to extracts from Cimicifuga species and particularly from Cimicifuga racemosa , which are suited for producing a ready-formulated drug for the selective treatment and/or prophylaxis of sexual hormone-related disorders of the uro-genital tract. The extracts in accordance with the invention are moreover suited for the treatment and/or prophylaxis of post-menopausal urinary bladder infections. They are furthermore indicated for the treatment of benign and malignant prostate hyperplasies.

1 . A method for alleviating a sexual hormone-related disorder of the uro-genital tract comprising the step of administering an estrogen-type organoselective medicament having at most a negligible uterotrophic effect, the medicament comprising an extract from a  Cimicifuga  species. 
   
   
       2 . The method of  claim 1  wherein the sexual hormone-related disorder of the uro-genital tract is a post-menopausally occurring disorder. 
   
   
       3 . The method of  claim 2  wherein the post-menopausally occurring disorder is selected from the group consisting of urinary bladder infection and dry vagina. 
   
   
       4 . The method of  claim 3  wherein the  Cimicifuga  species is selected from the group consisting of:  C. racemosa, C. foetida, C. dahurica, C. heracleifolia, C. simplex, C. japonica, C. europaea, C. acerina, C. elata, C. rubifolia.    
   
   
       5 . The method of  claim 4  wherein the  Cimicifuga  species is  C. racemosa.    
   
   
       6 . The method of  claim 1  wherein the extract is produced from a  Cimicifuga  species by extraction with an organic solvent. 
   
   
       7 . The method of  claim 1  wherein the extract is produced from a  Cimicifuga  species by extraction with a mixture of an organic solvent and water. 
   
   
       8 . The method of  claim 1  wherein the extract is produced from a  Cimicifuga  species by extraction with supercritical CO 2 . 
   
   
       9 . An estrogen-type organoselective medicament having at most a negligible uterotrophic effect, the medicament comprising an extract from a  Cimicifuga  species, the medicament alleviating a sexual hormone-related disorder of the uro-genital tract when administered. 
   
   
       10 . The medicament of  claim 9  wherein the sexual hormone-related disorder of the uro-genital tract is a post-menopausally occurring disorder. 
   
   
       11 . The medicament of  claim 10  wherein the post-menopausally occurring disorder is selected from the group consisting of urinary bladder infection and dry vagina. 
   
   
       12 . The medicament of  claim 9  wherein the  Cimicifuga  species is selected from the group consisting of:  C. racemosa, C. foetida, C. dahurica, C. heracleifolia, C. simplex, C. japonica, C. europaea, C. acerina, C. elata, C. rubifolia.    
   
   
       13 . The medicament of  claim 12  wherein the  Cimicifuga  species is  C. racemosa.    
   
   
       14 . The medicament of  claim 9  wherein the extract is produced from a  Cimicifuga  species by extraction with an organic solvent. 
   
   
       15 . The medicament of  claim 9  wherein the extract is produced from a  Cimicifuga  species by extraction with a mixture of an organic solvent and water. 
   
   
       16 . The medicament of  claim 9  wherein the extract is produced from a  Cimicifuga  species by extraction with supercritical CO 2 . 
   
   
       17 . An estrogen-type organoselective medicament, the medicament comprising an extract from a  Cimicifuga  species, the medicament alleviating a prostatic disorder selected from the group consisting of benign and malignant prostate hyperplasy. 
   
   
       18 . The medicament of  claim 17  wherein the  Cimicifuga  species is selected from the group consisting of:  C. racemosa, C. foetida, C. dahurica, C. heracleifolia, C. simplex, C. japonica, C. europaea, C. acerina, C. elata, C. rubifolia.    
   
   
       19 . The medicament of  claim 18  wherein the  Cimicifuga  species is C. 
   
   
       20 . The medicament of  claim 17  wherein the extract is produced from a  Cimicifuga  species by extraction with an organic solvent. 
   
   
       21 . The medicament of  claim 17  wherein the extract is produced from a  Cimicifuga  species by extraction with a mixture of an organic solvent and water. 
   
   
       22 . The medicament of  claim 17  wherein the extract is produced from a  Cimicifuga  species by extraction with supercritical CO 2 .