Immunoregulatory compositions

Abstract

The invention relates to compounds exhibiting immunoregulatory activity as determined by measuring the compound's ability to modulate production of NO by a cell. Preferred compounds include or consist of a sequence AAL AAQ AAG AAV wherein AAL is a substituted or unsubstituted non-polar amino acid selected from the group consisting of Ala and Leu; wherein AAQ is a substituted or unsubstituted amino acid selected from the group consisting of Gln, Pro, and Ala; wherein AAG is a substituted or unsubstituted amino acid Gly, and wherein AAV is a substituted or unsubstituted non-polar amino acid selected from the group consisting of Val and Ala. In certain embodiments, the compound consists of a tripeptide selected from the group AQG, MTR, VVC, and mixtures thereof.

1 . A composition comprising one or more purified or isolated peptides of the sequence LAGV (SEQ ID NO:26) or salt thereof. 
     
     
         2 . A composition comprising a purified or isolated peptide of the sequence LAGV (SEQ ID NO:26) or salt thereof. 
     
     
         3 . A composition comprising:
 a purified peptide consisting of the sequence of SEQ ID NO:26, or a salt thereof.   
     
     
         4 . The composition of  claim 3 , further comprising:
 a pharmaceutically acceptable carrier, diluent and/or excipient.