Methods for treating macular degeneration using 4-(amino)-2-(2,6-dioxo(3-piperidyle))-isoindoline-1,3-dione

Abstract

Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, alone or in combination with a second active agent and/or surgery.

1 - 16 . (canceled) 
   
   
       17 . A method of treating macular degeneration, which comprises administering to a patient having macular degeneration a therapeutically effective amount of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione of the formula: 
     
       
         
         
             
             
         
       
       or an enantiomer thereof. 
     
   
   
       18 . The method of  claim 17 , wherein the compound is 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione. 
   
   
       19 . The method of  claim 17 , wherein the enantiomer is an enantiomerically pure R isomer. 
   
   
       20 . The method of  claim 17 , wherein the enantiomer is an enantiomerically pure S isomer. 
   
   
       21 . The method of  claim 17 , wherein the compound is administered orally. 
   
   
       22 . The method of  claim 21 , wherein the compound is administered in the form of a capsule or tablet. 
   
   
       23 . The method of  claim 17 , wherein the compound is administered in an amount of from about 0.1 to about 300 mg/kg per day. 
   
   
       24 . The method of  claim 23 , wherein the compound is administered in an amount of from about 0.5 to about 50 mg/kg per day. 
   
   
       25 . The method of  claim 23 , wherein the compound is administered in an amount of from about 0.1 to about 2 mg/kg per day. 
   
   
       26 . The method of  claim 17 , wherein the compound is administered orally, opthalmically, parenterally, transdermally, mucosally, nasally, buccally, rectally, sublingually, topically or vaginally. 
   
   
       27 . The method of  claim 17 , wherein the compound is administered in the form of a cream, a lotion, an ointment, a patch, a gel, a paste, a liquid, a solution, an emulsion, a suspension, a dispersion, a spray, or a drop.