Diagnostic Agents For Positron Emission Imaging Using Radiolabeled Halogenated Xanthenes

Abstract

New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

1 - 7 . (canceled) 
   
   
       8 . A diagnostic agent comprising at least one positron emitting radiolabeled halogenated xanthene as a primary active component,
 wherein said radiolabeled halogenated xanthene is a derivative of Rose Bengal having the formula C 20 H 2 O 5 F 0 Cl 4 Br 0 I 4 , R 1 ,R 2 , where R 1  or R 2  are at least one targeting moiety attached to Rose Bengal, and   wherein said at least one targeting moiety is selected from the group consisting of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), amino acids, proteins, antibodies, ligands, haptens, carbohydrate receptors, carbohydrate complexing agents, lipid receptors, lipid complexing agents, protein receptors, protein complexing agents, chelators, short-chain aliphatic hydrocarbons, long-chain aliphatic hydrocarbons, and aromatic hydrocarbons.   
   
   
       9 . The agent of  claim 8  wherein said radiolabled halogenated xanthene is present in a concentration of greater than about 0.001% to less than about 20%. 
   
   
       10 . (canceled)