Vaccine For Periodontal Disease

Abstract

The present invention relates to novel bacterial isolates identified by their 16S rRNA DNA, that cause periodontal disease in companion animals, polynucleotide sequences contained therein, polypeptides encoded by such polynucleotide sequences and vaccines comprising such bacteria, polynucleotides, or polypeptides. Also provided are methods for treating and preventing periodontal disease and kits for detecting and treating periodontal disease kits for detecting and preventing periodontal disease. In addition, methods for assessing the efficacy of a vaccine against periodontal diseases in an animal are provided.

1 .- 75 . (canceled) 
     
     
         76 . A vaccine for treating or preventing periodontal disease in dogs and cats comprising inactivated whole cell preparations of  P. gulae  B43 , P. salivosa  B104 and  P. denticanis  B106 and a pharmaceutically acceptable carrier. 
     
     
         77 . The vaccine of  claim 76 , wherein the bacteria are inactivated by formalin. 
     
     
         78 . The vaccine of  claim 76 , further comprising at least one of Canine Distemper Virus (CDV), Canine Adenovirus-2 (CAV-2), Canine Parvovirus (CPV), Canine Parainfluenza Virus (CPI), or Canine Coronavirus (CCV). 
     
     
         79 .- 92 . (canceled) 
     
     
         93 . The vaccine according to  claim 76 , further comprising an adjuvant.