Blood group antigen fusion polypeptides and methods of use thereof

Abstract

The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection.

1 . An absorber comprising a fusion polypeptide, wherein the fusion polypeptide comprises a first polypeptide operably linked to a second polypeptide, wherein the first polypeptide:
 (a) is a mucin polypeptide and   (b) is glycosylated by an α1,2 fucosyltransferase and   the second polypeptide comprises at least a region of an immunoglobulin polypeptide.   
     
     
         2 . A method removing an antibody from a biological sample, the method comprising
 (a) contacting a biological sample with the absorber of  claim 1  to form an absorber-antibody complex; and   (b) removing the complex from the biological sample thereby removing the antibody from the biological sample.