Methods for treating pustular conditions of the skin

Abstract

The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

1 . A method for treating a pustular condition of the skin in a patient in need thereof comprising administering to the patient a therapeutically effective amount of one or more compositions comprising ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom. 
   
   
       2 . The method of  claim 1  wherein such treatment causes a reduction in inflammation of the pustular condition. 
   
   
       3 . The method of  claim 1  wherein such treatment causes accelerated healing of the pustular condition. 
   
   
       4 . The method of  claim 1  wherein such treatment causes reduced scarring of the skin following healing of the pustular condition. 
   
   
       5 . The method of  claim 1  wherein the pustular condition of the skin is acne. 
   
   
       6 . The method of  claim 1  wherein the ECS cells are AMP cells. 
   
   
       7 . The method of  claim 6  wherein the AMP cells are pooled AMP cells. 
   
   
       8 . The method of  claim 1  wherein the conditioned media is ACCS. 
   
   
       9 . The method of  claim 8  wherein the ACCS is pooled ACCS. 
   
   
       10 . The method of  claim 1  wherein the ECS cells, conditioned media derived therefrom, cell lysate derived therefrom or cell products derived therefrom are administered in combination with other agents or therapies. 
   
   
       11 . The method of  claim 10  wherein the other agents are active agents. 
   
   
       12 . The method of  claim 11  wherein the active agents are steroids, topical bactericidal agents, or antibiotics. 
   
   
       13 . The method of  claim 11  wherein the other therapy is mechanical exfoliation, chemical exfoliation, phototherapy or laser therapy. 
   
   
       14 . The method of  claim 1  wherein the ECS cells are partially differentiated or fully differentiated. 
   
   
       15 . The method of  claim 6  wherein the AMP cells are partially differentiated or fully differentiated.