US2009005538A1PendingUtilityA1

Apoptosis-Inducing Agent for Prostate Cancer Cells

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Assignee: KUMON HIROMIPriority: Mar 15, 2005Filed: Jan 10, 2006Published: Jan 1, 2009
Est. expiryMar 15, 2025(expired)· nominal 20-yr term from priority
Inventors:Hiromi KumonNam-Ho HuhMasakiyo SakaguchiYasutomo Nasu
C07K 14/4747A61K 38/00A61P 35/00A61P 35/04
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Claims

Abstract

According to the present invention, an apoptosis-inducing agent for prostate cancer comprising REIC/Dkk-3 DNA or an REIC/Dkk-3 protein, and a therapeutic agent for prostate cancer and an agent for inhibiting prostate cancer metastasis that comprise such apoptosis-inducing agent are provided. An apoptosis-inducing agent for prostate cancer, comprising, as an active ingredient, an REIC/Dkk-3 protein (a) or (b) or REIC/Dkk-3 DNA (c) or (d): (a) a protein consisting of the amino acid sequence represented by SEQ ID NO: 2; (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by substitution or deletion of 1 or more amino acids; (c) DNA consisting of the nucleotide sequence represented by SEQ ID NO: 1; or (d) DNA that hybridizes under stringent conditions to DNA consisting of a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 1 and encodes a protein having apoptosis activity; and a therapeutic agent for prostate cancer comprising such apoptosis-inducing agent are provided

Claims

exact text as granted — not AI-modified
1 . An apoptosis-inducing agent for prostate cancer, comprising, as an active ingredient, the following REIC/Dkk-3 protein:
 (a) a protein consisting of the amino acid sequence represented by SEQ ID NO: 2; or   (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by substitution, deletion, or addition of 1 or more amino acids and having apoptosis activity.   
     
     
         2 . A therapeutic agent for prostate cancer, comprising the apoptosis-inducing agent according to  claim 1 . 
     
     
         3 . An apoptosis-inducing agent for prostate cancer, comprising, as an active ingredient, the following REIC/Dkk-3 DNA:
 (c) DNA consisting of the nucleotide sequence represented by SEQ ID NO: 1; or   (d) DNA that hybridizes under stringent conditions to DNA consisting of a nucleotide sequence complementary to the nucleotide sequence represented by SEQ ID NO: 1 and encodes a protein having apoptosis activity.   
     
     
         4 . A therapeutic agent for prostate cancer, comprising the apoptosis-inducing agent according to  claim 3 . 
     
     
         5 . An agent for inhibiting prostate cancer metastasis, comprising the apoptosis-inducing agent according to  claim 1 . 
     
     
         6 . An agent for inhibiting prostate cancer metastasis, comprising the apoptosis-inducing agent according to  claim 3 . 
     
     
         7 . The therapeutic agent for prostate cancer according to  claim 2 , which is used in combination with hyperthermia. 
     
     
         8 . The agent for inhibiting prostate cancer metastasis according to  claim 5 , which is used in combination with hyperthermia. 
     
     
         9 . The therapeutic agent for prostate cancer according to  claim 4 , which is used in combination with hyperthermia. 
     
     
         10 . The agent for inhibiting prostate cancer metastasis according to  claim 6  which is used in combination with hyperthermia.

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