Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof

Abstract

A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1: and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule related to MTP for modulating inflammation and/or apoptosis.

1 - 15 . (canceled) 
   
   
       16 . A method for providing an immune response in a host, which comprises administering an amount effective to promote an immune response of a composition comprising an antigen and a tripeptide having the structure L-Ala-D-Glu-mesoDAP, or a biological derivative or a peptidomimetic thereof, wherein the amino acid Ala of said tripeptide is not linked to a N-acylmuramic acid. 
   
   
       17 - 18 . (canceled) 
   
   
       19 . The method of  claim 16 , wherein the host is human or a warm-blooded animal. 
   
   
       20 - 34 . (canceled) 
   
   
       35 . The method of  claim 16 , wherein the L-Ala is replaced with D-Ala. 
   
   
       36 . The method of  claim 16 , wherein the antigen is from a Gram negative bacterium. 
   
   
       37 . The method of  claim 36 , wherein the Gram negative bacterium is chosen from  Escherichia coli, Shigella flexneri, Neisseria meningitidis , and  Salmonella typhimurium.