Wound Healing

Abstract

A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound to a wound site or the skin, and optionally exposing the wound site or skin to light.

1 - 9 . (canceled) 
   
   
       10 . A method of cosmetic treatment comprising:
 a) applying or administering to an area to be treated an effective amount of a composition comprising a compound of Formula (I)   
     
       
         
         
             
             
         
       
     
     wherein:
 R 1 -R 6  each independently is selected from H, optionally substituted C 1-6 -alkyl, F, Cl, Br and I; 
 A and B each independently is selected from: 
 
     
       
         
         
             
             
         
       
     
     wherein:
 Q is selected from H and optionally substituted C 1-4 -alkyl; 
 Z is selected from C(R a ) 2 , O, S, SO 2  and NR a  in which R a  is selected from H and optionally substituted C 1-4 -alkyl; 
 R 7  and R 8  each independently is selected from H and optionally substituted C 1-6 -alkyl; 
 Y is a counteranion; and 
 p is 1, 2 or 3; and 
 b) optionally exposing the treated area to light. 
 
   
   
       11 . The method according to  claim 10 , wherein said cosmetic treatment is selected from skin rejuvenation, skin thickening, reduction of scar formation and birth mark removal. 
   
   
       12 . The method according to  claim 10 , wherein said cosmetic treatment is skin rejuvenation. 
   
   
       13 . The method according to  claim 10 , wherein said cosmetic treatment is skin thickening. 
   
   
       14 . The method according to  claim 10 , wherein said cosmetic treatment is reduction of scar formation. 
   
   
       15 . The method according to  claim 10 , wherein said cosmetic treatment is birth mark removal. 
   
   
       16 . The method according to  claim 10 , wherein said composition further comprises a pharmaceutically acceptable diluent or excipient. 
   
   
       17 . The method according to  claim 10 , wherein R 7  and R 8  are independently selected from optionally-substituted C 3-6  alkyl. 
   
   
       18 . The method according to  claim 10 , wherein A and B are of formula —NR 7 R 8 . 
   
   
       19 . The method according to  claim 10 , wherein Y is a counterion selected from F − , Br − , Cl − , I − , NO 3   − , SCN − , ClO 3   − , ClO 4   − , IO 3   − , BF 4   − , HSO 4   − , H 2 PO 4   − , CH 3 SO 4   − , N 3 , SO 4   2− , HPO 4   2− , PO 4   3− , acetate, lactate, citrate, tartrate, glycolate, glycerate, glutamate, β-hydroxyglutamate, glucouronate, gluconate, malate and aspartate. 
   
   
       20 . The method according to  claim 10 , wherein R 1 , R 2 , R 3 , R 4 , R 5  and R 6  each represents H, and A and B represent —NR 7 R 8  wherein R 7  and R 8  represent butyl. 
   
   
       21 . A method of cosmetic treatment comprising:
 a) applying or administering to an area to be treated an effective amount of a composition comprising a compound of Formula (1)   
     
       
         
         
             
             
         
       
     
     wherein:
 R 1 -R 6  each independently is selected from H, optionally substituted C 1-6 -alkyl, F, Cl, Br and I; 
 A and B each independently is selected from: 
 
     
       
         
         
             
             
         
       
     
     wherein:
 Q is selected from H and optionally substituted C 1-4 -alkyl; 
 Z is selected from C(R a ) 2 , O, S, SO 2 , NR a  in which R a  is selected from H and optionally substituted C 1-4 -alkyl; 
 R 7  and R 8  each independently is selected from optionally substituted C 3-6 -alkyl; 
 Y is a counteranion; and 
 p is 1, 2 or 3; and 
 b) optionally exposing the treated area to light.