US2009023893A1PendingUtilityA1

Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis

Assignee: HOUSE EAR INSTPriority: Nov 28, 2000Filed: Jul 16, 2008Published: Jan 22, 2009

Est. expiryNov 28, 2020(expired)· nominal 20-yr term from priority

Inventors:David J. Lim Haa-Yung Lee Paul J.L. Webster Ali Andalibi Jian Li Tomas Ganz Kiweon Cha

A61P 31/04A61K 38/40C12Y 302/01017A61K 38/47A61K 38/1729

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Abstract

The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.

Claims

exact text as granted — not AI-modified

1 . A pharmaceutical composition comprising a pharmacologically effective amount of EP2E polypeptide, wherein said amount of EP2E polypeptide is sufficient to treat a microbial infection in a mammal. 
     
     
         2 . The composition of  claim 1 , wherein said infection is selected from the group consisting of otitis media, paranasal sinusitis, labyrinthitis and meningitis. 
     
     
         3 . The composition of  claim 1 , wherein said EP2E polypeptide is synthesized chemically and refolded by oxidative refolding.

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