US2009023949A1PendingUtilityA1

Amorphous ibandronic acid

Assignee: BAYER THOMASPriority: Jun 23, 2004Filed: Jul 10, 2008Published: Jan 22, 2009

Est. expiryJun 23, 2024(expired)· nominal 20-yr term from priority

Inventors:Thomas Bayer Ben-Zion Dolitzky Revital Lifshitz-Liron Inna Perutski Michael Pinchasov

A61P 19/10A61P 19/08C07F 9/3873

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Abstract

Amorphous ibandronic acid is provided with methods for its preparation. The methods include dissolution of ibandronic acid in a solvent such as acetonitrile, DMSO, methanol, or water, and spray drying.

Claims

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1 . Amorphous ibandronic acid. 
   
   
       2 . A method of making amorphous ibandronic acid comprising the steps of subjecting a solution of ibandronic acid in a solvent selected from the group consisting of: acetonitrile (ACN), dimethylsulfoxide (DMSO), methanol, and water, to a solvent-removal step selected from vacuum evaporation, lyophilization, and spray drying. 
   
   
       3 . The process of  claim 2 , wherein the solvent is water. 
   
   
       4 . A method of making amorphous ibandronic acid comprising the step of spray drying an aqueous solution of ibandronic acid.

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