Non-absorbent articles containing additives

Abstract

Non-absorbent articles containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound such as cerulenin, triclosan, or hexachloroprene, for example, to substantially inhibit the production of TSST-1 by Gram positive bacteria.

1 . A tampon applicator comprising a non-absorbent material and an effective amount of a first active ingredient having the general formula: 
       
         
           
           
               
               
           
         
       
       wherein R 200  is a monovalent, saturated or unsaturated, substituted or unsubstituted hydrocarbyl moiety having from 1 to 15 carbon atoms which may or may not be interrupted with heteroatom, and the first active ingredient is effective in inhibiting the production of TSST-1 from Gram positive bacteria, and wherein the first active ingredient is present in an amount of from about 0.05 micromoles/gram of non-absorbent material to about 5 micromoles/gram of non-absorbent material. 
     
     
         2 - 4 . (canceled) 
     
     
         5 . The tampon applicator as set forth in  claim 1  wherein the first active ingredient has the structure of formula (II). 
     
     
         6 . The tampon applicator as set forth in  claim 5  wherein the first active ingredient is cerulenin (open structure). 
     
     
         7 . The tampon applicator as set forth in  claim 1  wherein the first active ingredient has the structure of formula (III). 
     
     
         8 . The tampon applicator as set forth in  claim 7  wherein the first active ingredient is cerulenin (closed structure). 
     
     
         9 . (canceled) 
     
     
         10 . (canceled) 
     
     
         11 . The tampon applicator as set forth in  claim 6  wherein the cerulenin (open structure) is present in an amount of from about 0.1 micromoles/gram of non-absorbent material to about 1 micromole/gram of non-absorbent material. 
     
     
         12 . The tampon applicator as set forth in  claim 8  wherein the cerulenin (closed structure) is present in an amount of from about 0.1 micromoles/gram of non-absorbent material to about 1 micromole/gram of non-absorbent material. 
     
     
         13 . A non-absorbent article comprising a non-absorbent substrate and an effective amount of a first active ingredient having the general formula: 
       
         
           
           
               
               
           
         
       
       wherein R 200  is a monovalent, saturated or unsaturated, substituted or unsubstituted hydrocarbyl moiety having from 1 to 15 carbon atoms which may or may not be interrupted with a heteroatom, and the first active ingredient is effective in inhibiting the production of TSST-1 from Gram positive bacteria, and wherein the first active ingredient is present in an amount of from about 0.05 micromoles/gram of non-absorbent article to about 5 micromoles/gram of non-absorbent article. 
     
     
         14 - 16 . (canceled) 
     
     
         17 . The non-absorbent article as set forth in  claim 13  wherein the first active ingredient has the structure of formula (II). 
     
     
         18 . The non-absorbent article as set forth in  claim 17  wherein the first active ingredient is cerulenin (open structure. 
     
     
         19 . The non-absorbent article as set forth in  claim 13  wherein the first active ingredient has the structure of formula (III). 
     
     
         20 . The non-absorbent article as set forth in  claim 19  wherein the first active ingredient is cerulenin (closed structure). 
     
     
         21 . (canceled) 
     
     
         22 . (canceled) 
     
     
         23 . The non-absorbent article as set forth in  claim 18  wherein the cerulenin (open structure) is present in an amount of from about 0.1 micromoles/gram of non-absorbent article to about 1 micromole/gram of non-absorbent article. 
     
     
         24 . The non-absorbent article as set forth in  claim 20  wherein the cerulenin (closed structure) is present in an amount of from about 0.1 micromoles/gram of non-absorbent article to about 1 micromole/gram of non-absorbent article. 
     
     
         25 . The non-absorbent article as set forth in  claim 13  wherein the first active ingredient is effective in substantially inhibiting the production of TSST-1 from  Staphylococcus aureus  bacteria. 
     
     
         26 . The non-absorbent article as set forth in  claim 13  wherein the non-absorbent article is selected from the group consisting of incontinence devices, barrier birth control devices, douches, contraceptive sponges, and tampon applicators. 
     
     
         27 . The non-absorbent article as set forth in  claim 13  wherein the first active ingredient reduces the formation of TSST-1 when the non-absorbent article is exposed to  S. aureus  by at least about 60%. 
     
     
         28 . The non-absorbent article as set forth in  claim 13  further comprising a pharmaceutically active material selected from the group consisting of antimicrobials, antioxidants, anti-parasitic agents, antipruritics, astringents, local anaesthetics and anti-inflammatory agents. 
     
     
         29 - 111 . (canceled) 
     
     
         112 . The non-absorbent article as set forth in  claim 13  further comprising an effective amount of a second active ingredient selected from the group consisting of glycerol monolaurate and myreth-3-myristate wherein said active ingredient is effective in substantially inhibiting the production of exoprotein from Gram positive bacteria. 
     
     
         113 - 141 . (canceled)