Ectoparasite control method

Abstract

This invention relates to a method of controlling or preventing infestations of ectoparasites, preferably hematophageous ectoparasites, on an animal by administering to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, or an N-oxide, or a pharmaceutically or veterinarily acceptable salt thereof, wherein R 1 is Me, Cl, Br or F; R 2 is F, Cl, Br, C 1 -C 4 haloalkyl or C 1 -C 4 haloalkoxy; R 3 is F, Cl or Br; R 4 is H; C 1 -C 4 alkyl, C 3 -C 4 alkenyl, C 3 -C 4 alkynyl, C 3 -C 5 cycloalkyl, or C 4 -C 6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CN, SMe, S(O)Me, S(O) 2 Me, and OMe; R 5 is H or Me; R 6 is H, F or Cl; and R 7 is H, F or Cl.

1 . A method of controlling or preventing infestation of a hematophagous ectoparasitic insect on a homeothermic animal by administering to the animal a composition comprising a parasiticidally effective amount of 3-bromo-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide or an N-oxide or pharmaceutically or veterinarily acceptable salt thereof. 
   
   
       2 . The method of  claim 1  wherein the hematophagous ectoparasitic insect is selected from the group consisting of fleas, ticks, lice mites, and biting flies. 
   
   
       3 . The method of  claim 1  wherein the administering is oral. 
   
   
       4 . The method of  claim 1  wherein the administering is parenteral. 
   
   
       5 . The method of  claim 1  wherein the administering is topical. 
   
   
       6 . The method of  claim 1  wherein the animal is a cat or dog. 
   
   
       7 . The method of  claim 1  wherein the animal is a herd animal. 
   
   
       8 . The method of any of  claims 1 - 7  wherein the composition comprises at least one additional component selected from the group consisting of solvents and/or carriers, emulsifiers and/or dispersing agents. 
   
   
       9 . The method of  claim 8  wherein the composition comprises at least one additional biologically active compound or agent. 
   
   
       10 . The method of  claim 9  wherein the additional biologically active compound or agent is selected from the group consisting of macrocyclic lactones, acetyl cholinesterase inhibitors, arthropod growth regulators, GABA-gated chloride channel antagonists, mitochondrial electron transport inhibitors, nicotinic acetylcholine agonists/antagonists/activator, oxidative phosphorylation inhibitors, anthelminthics, sodium channel modulators or other antiparasitic compounds. 
   
   
       11 . The method of  claim 10  wherein said biologically active compound is a macrocyclic lactone. 
   
   
       12 . The method of  claim 10  wherein said biologically active compound is an acetyl cholinesterase inhibitor selected from the group of organophosphates and carbamates. 
   
   
       13 . The method of  claim 10  wherein said biologically active compound is an arthropod growth regulator selected from the group of chitin synthesis inhibitors, ecdysone agonists/disruptors, lipid biosynthesis inhibitor and juvenile hormone mimics. 
   
   
       14 . The method of  claim 10  wherein said biologically active compound is a GABA-gated chloride channel antagonist. 
   
   
       15 . The method of  claim 10  wherein said biologically active compound is a mitochondrial electron transport inhibitor. 
   
   
       16 . The method of  claim 10  wherein said biologically active compound is a nicotinic acetylcholine agonist/antagonist/activator. 
   
   
       17 . The method of  claim 10  wherein said biologically active compound is an oxidative phosphorylation inhibitor. 
   
   
       18 . The method of  claim 10  wherein said biologically active compound is an anthelminthic. 
   
   
       19 . The method of  claim 10  wherein said biologically active compound is a sodium channel modulator.