Combinations of vasoprotective agents and formulations containing them

Abstract

Combinations of vasoprotective agents useful for the prevention and the treatment of vascular injuries induced by an excess of plasma lipids comprising polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.

1 . Pharmaceutical, dietetic or nutritional compositions comprising:
 one or more polycosanols or esters thereof, either pure or as extracts;   tocotrienol and/or lycopene, preferably tocotrienol;   one or more procyanidole oligomers optionally complexed with phospholipids;   a vegetable oil rich in ω-3, ω-6 unsaturated fatty acids.   
   
   
       2 . Compositions as claimed in  claim 1 , in which the vegetable oil is selected from  Enothera biennis, Ribes nigrum  or  Portulaca oleracea  oil. 
   
   
       3 . Compositions as claimed in  claim 2  in which the vegetable oil is  Enothera biennis  oil. 
   
   
       4 . Compositions as claimed in  claim 1 , further containing luteolin either per se or in the form of 7,3′, 4′-hydroxyethyl derivatives. 
   
   
       5 . Compositions as claimed in  claim 1  in which polycosanols are esterified with ferulic acid or other variously substituted cinnamates. 
   
   
       6 . Compositions as claimed in  claim 1  in which procyanidole oligomers derive from  Vitis vinifera, Camellia sinesis, Aesculus hippocastanum, Olea europa.    
   
   
       7 . Compositions as claimed in  claim 1 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       8 . Method for the preparation of hypocholesterolemizing and/or anti-atherosclerotic pharmaceutical, dietetic or nutritional compositions, which comprises using a combination of an effective amount of:
 one or more polycosanols, in the free or esterified form, either pure or extracts containing them;   tocotrienol and/or lycopene, preferably tocotrienol   one or more procyanidole oligomers optionally complexed with phospholipids;   a vegetable oil rich in ω-3, ω-6 unsaturated fatty acids.   
   
   
       9 . Compositions as claimed in  claim 2 , further containing luteolin either per se or in the form of 7,3′, 4′-hydroxyethyl derivatives. 
   
   
       10 . Compositions as claimed in  claim 3 , further containing luteolin either per se or in the form of 7,3′, 4′-hydroxyethyl derivatives. 
   
   
       11 . Compositions as claimed in  claim 2 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       12 . Compositions as claimed in  claim 3 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       13 . Compositions as claimed in  claim 4 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       14 . Compositions as claimed in  claim 5 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form. 
   
   
       15 . Compositions as claimed in  claim 6 , comprising 5 to 30 mg of polycosanols, 1 to 50 mg of tocotrienol or lycopene, 100 to 320 mg of proanthocyanidins complexed with phospholipids, 150 to 300 mg of vegetable oil, per unitary dosage form.