Doped-type metal sulfide phosphor nanoparticle, dispersion thereof, and method for producing the same

Abstract

A doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, the surface modifier being a compound of formula [I]: HS-L-W  Formula [I] wherein L is a divalent linking group; and W is COOM or NH 2 , in which M is a hydrogen atom, an alkali metal atom, or NX 4 , in which X is a hydrogen atom or an alkyl group; a dispersion containing the nanoparticle; and a method of producing the nanoparticle or the dispersion.

1 . A flourescent-labeling material comprising an affinity molecule coupled to a doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, wherein the doped-type metal sulfide phosphor nanoparticle is provided by a process comprising the steps of:
 carrying out a reaction of a doping metal ion and a matrix zinc ion, with a sulfide ion, in water and/or a hydrophilic solvent by a coprecipitation method, in which a solution comprising the doping metal ion and the matrix zinc ion and a solution comprising the sulfide ion are mixed under high speed stirring by a single-jet method or a double-jet method, wherein the total number of moles of the doping metal ion and the matrix zinc ion is greater than the number of moles of the sulfide ion by 2 to 40%; and   adding thereto a surface modifier comprising a compound represented by formula [I]:
   HS-L-W  Formula [I] 
   
     wherein L represents a divalent linking group; and W represents COOM or NH 2 , in which M represents a hydrogen atom, an alkali metal atom, or NX 4 , in which X represents a hydrogen atom or an alkyl group,
 wherein the number average particle diameter of the zinc sulfide phosphor nanoparticle is from 1 to 10 nm and the particle size distribution of the zinc sulfide phosphor nanoparticle is from 0 to 20% in terms of coefficient of variation. 
 
   
   
       2 . A method of producing a fluorescent-labeling material, comprising the step of:
 coupling an affinity molecule, to a terminal group of a surface modifier which covers a doped-type metal sulfide phosphor nanoparticle, whose surface is modified with the surface modifier, wherein the doped-type metal sulfide phosphor nanoparticle is produced by a process comprising the steps of:   carrying out a reaction of a doping metal ion and a matrix zinc ion, with a sulfide ion, in water and/or a hydrophilic solvent by a coprecipitation method, in which a solution comprising the doping metal ion and the matrix zinc ion and a solution comprising the sulfide ion are mixed under high speed stirring by a single-jet method or a double-jet method, wherein the total number of moles of the doping metal ion and the matrix zinc ion is greater than the number of moles of the sulfide ion by 2 to 40%; and   adding thereto a surface modifier comprising a compound represented by formula [I]:
   HS-L-W  Formula [I] 
   
     wherein L represents a divalent linking group; and W represents COOM or NH 2 , in which M represents a hydrogen atom, an alkali metal atom, or NX 4 , in which X represents a hydrogen atom or an alkyl group,
 wherein the number average particle diameter of the zinc sulfide phosphor nanoparticle is from 1 to 10 nm and the particle size distribution of the zinc sulfide phosphor nanoparticle is from 0 to 20% in terms of coefficient of variation.