Therapeutic Calcium Phosphate Particles in Use for Aesthetic of Cosmetic Medicine, and Methods of Manufacture and Use

Abstract

Calcium phosphate (“CAP”) particles for use in cosmetic, nutraceutic or aesthetic medicine. The particles may be used as carriers for cosmetic, nutraceutic or a factors, as controlled release matrices for the material, and as fillers in cosmetic treatments. The particles may be applied topically or injected or by any other appropriate delivery method.

1 . A composition for treating one or more skin conditions, comprising:
 a calcium phosphate particle having a diameter of between about 200 nm-4000 nm having an aesthetic factor comprising a wrinkle treatment, a muscle relaxant, a skin filler, a dermal stimulant, a topical treatment, a vitamin, mineral, or herb, or a vein treatment. at least partially coating the particle or impregnating the particle or both.   
     
     
         2 . The composition of  claim 1 , wherein the composition is adapted to be delivered to a layer of skin via topical delivery or via injection. 
     
     
         4 . The composition of  claim 1 , wherein the calcium phosphate particle is smooth without any surface irregularities larger than 100 nm. 
     
     
         5 . The composition of  claim 1 , wherein the calcium phosphate particle is spherical, round, or oval in shape. 
     
     
         6 . The composition of  claim 1 , wherein the calcium phosphate particle is coated or has at least a partial layer of a surface modifying agent covering the particle. 
     
     
         7 . The composition of  claim 6 , wherein the surface modifying agent is a basic sugar, a modified sugar, an oligonucleotide, a carbohydrate, a carbohydrate derivative, cellobiose, or polyethylene glycol. 
     
     
         8 . The composition of  claim 1 , wherein the calcium phosphate particle is smooth or substantially smooth. 
     
     
         9 . A method for filling fine lines or wrinkles in the skin, comprising:
 (a) providing a composition comprising calcium phosphate particles having a diameter between 200 nm and 4000 nm;   (b) injecting the composition comprising calcium phosphate particles into the line or wrinkle.   
     
     
         10 . The method of  claim 9 , wherein the composition further comprises an aesthetic factor. 
     
     
         11 . The method of  claim 10 , wherein the aesthetic factor comprises a wrinkle treatment, a muscle relaxant, a skin filler, a dermal stimulant, a topical treatment, a vitamin, mineral, or herb, or a vein treatment. 
     
     
         13 . The method of  claim 9 , wherein the calcium phosphate particles are smooth without any surface irregularities larger than 100 nm. 
     
     
         14 . The method of  claim 9 , wherein the calcium phosphate particles are spherical, round, or oval in shape. 
     
     
         15 . The method of  claim 9 , wherein the calcium phosphate particles are smooth or substantially smooth.