Extract of the Family Dioscoreaceae and Composition for Preventing or Treating Peripheral Neuropathy Comprising the Same

Abstract

An extract of the family Dioscoreaceae useful for preventing or treating the peripheral neuropathy; and a pharmaceutical composition or food composition comprising the extract are provided. In addition, a pharmaceutical composition or food composition useful for preventing or treating the peripheral neuropathy comprising a compound isolated from the extract of the family Dioscoreaceae is provided.

1 . An extract of a family Dioscoreaceae for preventing or treating the peripheral neuropathy, the family Dioscoreaceae being at least one selected from the group consisting of  Dioscorea nipponica, Dioscorea septembloba, Dioscorea quinqueoloba, Dioscorea batatas, Dioscorea japonica, Dioscorea bulbifera, Dioscorea tokoro , and  Dioscorea tenuipes.    
   
   
       2 . The extract of  claim 1 , wherein the family Dioscoreaceae is  Dioscorea nipponica, Dioscorea quinqueoloba , or  Dioscorea tokoro.    
   
   
       3 . The extract of  claim 1 , wherein the peripheral neuropathy is the multiple neuropathy. 
   
   
       4 . The extract of  claim 1 , wherein the extract is obtained by performing an extraction process which comprises extracting a whole part, root, or aerial part of the family Dioscoreaceae with a first extraction solvent selected from the group consisting of water, C 1 -C 4  alcohol, and a mixture of water and a C 1 -C 4  alcohol. 
   
   
       5 . The extract of  claim 4 , wherein the extract is obtained by performing an extraction process which comprises extracting the root of the family Dioscoreaceae with the first extraction solvent. 
   
   
       6 . The extract of  claim 4 , wherein the first extraction solvent is a mixture of water and methanol or a mixture of water and ethanol. 
   
   
       7 . The extract of  claim 4 , wherein the extraction process further comprises dispersing the extract obtained by the extraction with the first extraction solvent in water, and extracting with a water-saturated C 1 -C 4  alcohol (second extraction solvent). 
   
   
       8 . The extract of  claim 7 , wherein the second extraction solvent is water-saturated butanol. 
   
   
       9 . A pharmaceutical composition for preventing or treating the peripheral neuropathy, which comprises a therapeutically effective amount of the extract of  claim 1 , and a pharmaceutically acceptable carrier. 
   
   
       10 . A food composition for preventing or treating the peripheral neuropathy, which comprises the extract of  claim 1 , as an active ingredient. 
   
   
       11 . A pharmaceutical composition for preventing or treating the peripheral neuropathy, which comprises a therapeutically effective amount of a compound represented by Formula 1 or salt thereof; and a pharmaceutically acceptable carrier: 
     
       
         
         
             
             
         
       
     
     wherein R is a hydrogen atom, a C 1 -C 4  alkyl group, or a saccharide. 
   
   
       12 . The pharmaceutical composition of  claim 11 , wherein R is a hydrogen atom. 
   
   
       13 . The pharmaceutical composition of  claim 11 , wherein the saccharide is selected from the group consisting of glucose, fructose, mannose, galactose, ribose, cellulose, glycogen, sucrose, maltose, and lactose. 
   
   
       14 . A food composition for preventing or treating the peripheral neuropathy, which comprises a compound represented by Formula 1 or salt thereof as an active ingredient: 
     
       
         
         
             
             
         
       
     
     wherein R is a hydrogen atom, a C 1 -C 4  alkyl group, or a saccharide. 
   
   
       15 . The food composition of  claim 14 , wherein R is a hydrogen atom. 
   
   
       16 . The food composition of  claim 14 , wherein the saccharide is selected from the group consisting of glucose, fructose, mannose, galactose, ribose, cellulose, glycogen, sucrose, maltose, and lactose.