Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid

Abstract

Disclosed are pharmaceutical compositions containing clodronic acid and hyaluronic acid or their salts as active constituents, mixed with suitable vehicles.

1 . Pharmaceutical compositions comprising clodronic acid and hyaluronic acid or their salts as active constituents, mixed with suitable vehicles. 
   
   
       2 . Compositions as claimed in  claim 1 , comprising 0.5 to 5 mg of clodronic acid or its salts. 
   
   
       3 . Compositions as claimed in  claim 2 , comprising 1 mg of clodronic acid or its salts. 
   
   
       4 . Compositions as claimed in  claim 2 , comprising 3 mg of clodronic acid or its salts. 
   
   
       5 . Compositions as claimed in  claim 1 , comprising sodium clodronate. 
   
   
       6 . Compositions as claimed in  claim 1 , comprising 10 to 30 mg of hyaluronic acid or its salts. 
   
   
       7 . Compositions as claimed in  claim 6 , comprising hyaluronic acid or its salts having molecular weight from 0.4×10 3  to 6×10 3  kDa. 
   
   
       8 . Compositions as claimed in  claim 7 , comprising hyaluronic acid or its salts having molecular weight from 0.4×10 3  to 1.5×10 3  kDa. 
   
   
       9 . Compositions as claimed in  claim 8 , comprising hyaluronic acid or its salts having molecular weight of approx 0.6×10 3  kDa. 
   
   
       10 . (canceled) 
   
   
       11 . (canceled) 
   
   
       12 . (canceled) 
   
   
       13 . (canceled) 
   
   
       14 . (canceled) 
   
   
       15 . (canceled) 
   
   
       16 . (canceled) 
   
   
       17 . (canceled) 
   
   
       18 . Compositions as claimed in  claim 9 , comprising hyaluronic acid or its salts having molecular weight of approx 0.9×10 3  kDa. 
   
   
       19 . Compositions as claimed in  claim 6 , comprising sodium hyaluronate. 
   
   
       20 . Compositions as claimed in  claim 1 , comprising sodium clodronate and sodium hyaluronate. 
   
   
       21 . Compositions as claimed in  claim 1 , which are suitable for the intra-articular administration. 
   
   
       22 . Compositions as claimed in  claim 1 , in the form of disposable syringes. 
   
   
       23 . A method of treatment of osteoarthritis which comprises the administration by the intra-articular route of an effective amount of a combination of clodronic acid and hyaluronic acid or their salts to a subject in need thereof.