Polymorphic form xvi of fexofenadine hydrochloride

Abstract

Provided is a crystalline (polymorphic) form of fexofenadine hydrochloride, denominated fexofenadine hydrochloride Form XVI.

1 - 10 . (canceled) 
   
   
       11 . The A pharmaceutical formulation comprising an effective amount of crystalline fexofenadine hydrochloride hydrate having a PXRD pattern with peaks at 10.1, 15.2, 18.6, 19.2, 20.1±0.2 degrees two theta, a pharmaceutically acceptable excipient and pseudoephedrine hydrochloride. 
   
   
       12 . A method of inhibiting binding between an H 1  receptor and histamine in a patient suffering from contraction of the bronchi, vasodilation, itching or other inflammation responses to histamine comprising administering to the patient a pharmaceutical formulation comprising an effective amount of crystalline fexofenadine hydrochloride hydrate having a PXRD pattern with peaks at 10.1, 15.2, 18.6, 19.2, 20.1±0.2 degrees two theta, and a pharmaceutically acceptable excipient. 
   
   
       13 - 54 . (canceled)