Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration

Abstract

Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.

1 . A pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. 
   
   
       2 . The composition in accordance to  claim 1  wherein the compound is administered between about 2.5 mg to about 10 mg of compound per kilogram of subject body weight. 
   
   
       3 . The composition in accordance to  claim 1 , wherein the therapeutically effective amount of pterostilbene is administered via a diet of  Vaccinium  berries. 
   
   
       4 . The composition in accordance with  claim 3 , wherein the  Vaccinium  berries are blueberries. 
   
   
       5 . A method for treating oxidative stress, the method comprising administering a therapeutically effective amount of a substantially pure compound of pterostilbene, wherein oxidative stress for a subject is reduced. 
   
   
       6 . The method as recited in  claim 5  wherein the therapeutic effective amount is between about 2.5 mg to about 10 mg of compound per kilogram of subject body weight. 
   
   
       7 . The method as recited in  claim 5  wherein the compound increases subject acetylcholine receptor activity. 
   
   
       8 . The method as recited in  claim 5  wherein dopamine release does not decrease upon subjecting the subject to an oxidative stressor. 
   
   
       9 . The method as recited in  claim 5  wherein pterostilbene is administered via a diet of  Vaccinium  berries. 
   
   
       10 . The method as recited in  claim 9  wherein the  Vaccinium  berries are blueberries. 
   
   
       11 . The method as recited in  claim 5  wherein pterostilbene increases calcium buffering ability of muscarinic receptor subtypes. 
   
   
       12 . The method as recited in  claim 11  wherein the muscarinic subtype is M1. 
   
   
       13 . A method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject is increases. 
   
   
       14 . The method as recited in  claim 13  wherein the therapeutic effective amount is of pterostilbene is about 10 mg of compound per kilogram of subject body weight. 
   
   
       15 . The method of  claim 13  wherein pterostilbene is administered with a pharmaceutical earner. 
   
   
       16 . The method of  claim 13  wherein pterostilbene is administered with a nutraceutical carrier. 
   
   
       17 . The method of  claim 5  wherein pterostilbene is derived from botanical plants.