Transdermal absorption enhancer

Abstract

An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.

1 . A transdermal absorption enhancer, characterized in that, lyotropic liquid crystal is an effective ingredient. 
   
   
       2 . The transdermal absorption enhancer according to  claim 1 , wherein said lyotropic liquid crystal contains 5% by weight to 80% by weight of a surfactant and 5% by weight to 80% by weight of water. 
   
   
       3 . The transdermal absorption enhancer according to  claim 2 , wherein said surfactant is a nonionic surfactant and/or lecithin. 
   
   
       4 . The transdermal absorption enhancer according to  claim 3 , wherein said nonionic surfactant is at least one member selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester and polyoxyethylene hydrogenated castor oil. 
   
   
       5 . The transdermal absorption enhancer according to  claim 2 , wherein said lyotropic liquid crystal further contains 1% by weight to 80% by weight of oil. 
   
   
       6 . The transdermal absorption enhancer according to  claim 5 , wherein said oil is squalane. 
   
   
       7 . The transdermal absorption enhancer according to  claim 2 , wherein said lyotropic liquid crystal further contains 1% by weight to 55% by weight of a polyhydric alcohol. 
   
   
       8 . The transdermal absorption enhancer according to claim  7 , wherein said polyhydric alcohol is glycerol. 
   
   
       9 . The transdermal absorption enhancer according to  claim 2 , wherein said lyotropic liquid crystal further contains 0.01% by weight to 10% by weight of an auxiliary surfactant. 
   
   
       10 . The transdermal absorption enhancer according to  claim 9 , wherein said auxiliary surfactant is cholesterol. 
   
   
       11 . A transdermal absorption composition, characterized in that, lyotropic liquid crystal is compounded with an active ingredient. 
   
   
       12 . The transdermal absorption composition according to  claim 11 , wherein said active ingredient is at least one member selected from the group consisting of organic compound, peptide, protein, oligonucleotide, DNA and RNA. 
   
   
       13 . The transdermal absorption composition according to  claim 11 , wherein said active ingredient is a macromolecular substance where molecular weight is not less than 1,000 or a water-soluble substance. 
   
   
       14 . The transdermal absorption composition according to  claim 11 , wherein said active ingredient is compounded in a form of being included in the inside of fine particles of inorganic acid salt with divalent metal. 
   
   
       15 . The transdermal absorption composition according to  claim 11 , wherein said active ingredient is compounded in an amount of 0.01% by weight to 50% by weight to the lyotropic liquid crystal.