Method for suppressing cancer cell metastasis and pharmaceutical composition for use in the method

Abstract

The present invention provides a novel method for inhibiting cancer cell metastasis using an antibody against TM7XN1, a pharmaceutical composition to be used for the method, and a cancer-metastasis-suppressing agent comprising an antibody against TM7XN1 as an active ingredient.

1 . A cancer-metastasis-suppressing agent, comprising an antibody against TM7XN1 as an active ingredient. 
     
     
         2 . The cancer-metastasis-suppressing agent according to  claim 1 , wherein a cell of the cancer expresses TM7XN1 on its surface. 
     
     
         3 . The cancer-metastasis-suppressing agent according to  claim 1  or  2 , wherein the cancer can metastasize to the bone. 
     
     
         4 . The cancer-metastasis-suppressing agent according to  claim 1  or  2 , wherein the cancer can metastasize to the spleen. 
     
     
         5 . The cancer-metastasis-suppressing agent according to any one of  claims 1  to  4 , wherein the cancer is selected from the group consisting of mammary cancer, prostate cancer, lung cancer, thyroid gland cancer, gastric cancer, malignant melanoma, neuroblastoma, multiple myeloma, acute myeloid leukemia, and pancreatic cancer. 
     
     
         6 . The cancer-metastasis-suppressing agent according to any one of  claims 1  to  5 , being capable of suppressing the metastasis of a cancer cell to the bone marrow. 
     
     
         7 . The cancer-metastasis-suppressing agent according to any one of  claims 1  to  5 , being capable of suppressing the metastasis of a cancer cell to the spleen. 
     
     
         8 . A method for suppressing a cancer metastasis, comprising administering the cancer-metastasis-suppressing agent according to any one of  claims 1  to  7  to a non-human animal with cancer.