US2009082257A1PendingUtilityA1

MalPEG-Hb conjugate- containing compositions for delivering carbon monoxide (CO) to cells

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Assignee: SANGART INCPriority: Mar 7, 2005Filed: Sep 18, 2008Published: Mar 26, 2009
Est. expiryMar 7, 2025(expired)· nominal 20-yr term from priority
Inventors:Robert M. Winslow
A61K 33/00A61K 38/42A61K 47/6445A61K 47/60A61P 9/12A61P 9/00
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Claims

Abstract

The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.

Claims

exact text as granted — not AI-modified
1 - 21 . (canceled) 
   
   
       22 . A carbon monoxide-hemoglobin (CO-Hb) complex that is useful for delivering carbon monoxide to blood cells, comprising:
 hemoglobin (Hb);   malemidyl-activated polyethylene glycol (MalPEG) conjugated to the Hb to form surface-modified MalPEG-Hb conjugates; and   carbon monoxide (CO) liganded to the Hb;   wherein the MalPEG-Hb binds CO more tightly than native unmodified hemoglobin from the same source when measured under the same conditions.   
   
   
       23 . The complex according to  claim 22 , wherein the MalPEG is maleimidyl-activated polyethylene glycol having an average molecular weight of about 5000 (MalPEG 5000). 
   
   
       24 . A pharmaceutical composition comprising the CO-Hb complex according to  claim 22 , and a pharmaceutically acceptable carrier.

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