Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient

Abstract

(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for overactive bladder.

1 . A remedy for overactive bladder comprising (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or a salt thereof as an active ingredient. 
   
   
       2 . The remedy according to  claim 1 , wherein it is a remedy for overactive bladder as a result of benign prostatic hyperplasia. 
   
   
       3 . The remedy according to  claim 1 , wherein it is a remedy for urinary urgency. 
   
   
       4 . The remedy according to  claim 1 , wherein it is a remedy for urinary incontinence. 
   
   
       5 . The remedy according to  claim 1 , wherein it is a remedy for pollakiuria. 
   
   
       6 . A remedy for overactive bladder comprising a free substance of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide as an active ingredient. 
   
   
       7 . The remedy according to  claim 6 , wherein it is a remedy for overactive bladder as a result of benign prostatic hyperplasia. 
   
   
       8 . The remedy according to  claim 6 , wherein it is a remedy for urinary urgency. 
   
   
       9 . The remedy according to  claim 6 , wherein it is a remedy for urinary incontinence. 
   
   
       10 . The remedy according to  claim 6 , wherein it is a remedy for pollakiuria.