Methods and Compositions for Use in Treating Cancer

Abstract

The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.

1 . A method of treating cancer in a patient, said method comprising administering to said patient a compound having the formula: 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof, in combination with a second approach to treatment. 
   
   
       2 . The method of  claim 1 , wherein said second approach to treatment comprises administration of a chemotherapeutic drug to said patient. 
   
   
       3 . The method of  claim 2 , wherein said chemotherapeutic drug is selected from the group consisting of antimetabolites, antibiotics, alkylating agents, plant alkaloids, and hormonal agents. 
   
   
       4 . The method of  claim 3 , wherein said chemotherapeutic drug is an antimetabolite. 
   
   
       5 . The method of  claim 4 , wherein said antimetabolite is gemcitabine. 
   
   
       6 . The method of  claim 5 , wherein said cancer is non-small cell lung carcinoma, pancreatic cancer, or metastatic breast cancer. 
   
   
       7 . The method of  claim 4 , wherein said antimetabolite is capecitabine. 
   
   
       8 . The method of  claim 7 , wherein said cancer is breast cancer or colorectal cancer. 
   
   
       9 . The method of  claim 3 , wherein said antibiotic is an anthracycline. 
   
   
       10 . The method of  claim 9 , wherein said anthracycline is doxorubicin. 
   
   
       11 . The method of  claim 10 , wherein said cancer is breast cancer. 
   
   
       12 . The method of  claim 3 , wherein said chemotherapeutic drug is an alkylating agent. 
   
   
       13 . The method of  claim 12 , wherein said alkylating agent is carboplatinum or cisplatinum. 
   
   
       14 . The method of  claim 13 , wherein said cancer is non-small cell lung cancer or ovarian cancer. 
   
   
       15 . The method of  claim 3 , wherein said chemotherapeutic drug is a plant alkaloid. 
   
   
       16 . The method of  claim 15 , wherein said plant alkaloid is irinotecan. 
   
   
       17 . The method of  claim 16 , wherein said cancer is colorectal cancer. 
   
   
       18 . The method of  claim 15 , wherein said plant alkaloid is topotecan. 
   
   
       19 . The method of  claim 18 , wherein said cancer is ovarian cancer or non-small cell lung cancer. 
   
   
       20 . The method of  claim 1 , wherein said second approach to treatment comprises administration of an anticoagulant to said patient. 
   
   
       21 . The method of  claim 20 , wherein said anticoagulant is heparin. 
   
   
       22 . A composition comprising a compound having the formula: 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof, in combination with a second chemotherapeutic drug. 
   
   
       23 . The composition of  claim 22 , wherein said chemotherapeutic drug is selected from the group consisting of antimetabolites, antibiotics, alkylating agents, plant alkaloids, and hormonal agents. 
   
   
       24 . The composition of  claim 23 , wherein said chemotherapeutic drug is an antimetabolite. 
   
   
       25 . The composition of  claim 24 , wherein said antimetabolite is gemcitabine. 
   
   
       26 . The composition of  claim 24 , wherein said antimetabolite is capecitabine. 
   
   
       27 . The composition of  claim 23 , wherein said antibiotic is an anthracycline. 
   
   
       28 . The composition of  claim 27 , wherein said anthracycline is doxorubicin. 
   
   
       29 . The composition of  claim 23 , wherein said chemotherapeutic drug is an alkylating agent. 
   
   
       30 . The composition of  claim 29 , wherein said alkylating agent is carboplatinum or cisplatinum. 
   
   
       31 . The composition of  claim 23 , wherein said chemotherapeutic drug is a plant alkaloid. 
   
   
       32 . The composition of  claim 31 , wherein said plant alkaloid is irinotecan. 
   
   
       33 . The composition of  claim 31 , wherein said plant alkaloid is topotecan.