Angelicae Sinensis Extracts Useful for Treatment of Cancers

Abstract

An acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, are administered alone or in combination with one or more chemotherapy drugs and are effective in treating cancers.

1 . A pharmaceutical composition for inhibiting proliferation of cancer cells, comprising an active ingredient consisting essentially of n-butylidenephthalide alone. 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the cancer cells is selected from the group consisting of human malignant glioblastoma, colorectal, leukemia, neuroblastoma, hepatoma, breast, ovarian and lung cancer. 
     
     
         3 . A pharmaceutical composition for inhibiting proliferation of cancer cells, comprising an active ingredient consisting essentially of n-butylidenephthalide alone; and one or more chemotherapy drugs. 
     
     
         4 . The pharmaceutical composition of  claim 3 , wherein the cancer cells is selected from the group consisting of human malignant glioblastoma, colorectal, leukemia, neuroblastoma, hepatoma, breast, ovarian and lung cancer. 
     
     
         5 . A method for inhibiting cancer cells proliferation and migration comprising administering an active ingredient consisting essentially of n-butylidenephthalide alone to the cancer cell. 
     
     
         6 . The method of  claim 5 , wherein the cancer cells are selected from the group consisting of human malignant glioblastoma, colorectal, leukemia, neuroblastoma, hepatoma, breast, ovarian and lung cancer. 
     
     
         7 . The method of  claim 5 , wherein the n-butylidenephthalide is administered via an oral, parenteral, intravenous (iv), intraperitoneal (ip), intramuscular (im), subcutaneous (sc), pulmonary, transdermal, buccal, nasal, sublingual, ocular, rectal or vaginal route. 
     
     
         8 . The method of  claim 5 , wherein the n-butylidenephthalide is administered via an oral, parenteral, or intravenous route.