Treatment of post-stroke muscle pain

Abstract

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

1 . A method for treating pain associated with muscle spasms secondary to stroke in a patient in need thereof, the method comprising the step of administering a therapeutically effective amount of a botulinum toxin to muscles of the patient having muscle spasms secondary to stroke, thereby treating pain associated with muscle spasms secondary to stroke. 
   
   
       2 . The method of  claim 1 , wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C, D, E, F and G. 
   
   
       3 . The method of  claim 1 , wherein the botulinum toxin is botulinum toxin type A. 
   
   
       4 . The method of  claim 1 , wherein the amount of botulinum toxin is between about 0.01 to about 1000 units. 
   
   
       5 . The method of  claim 1 , wherein the amount of botulinum toxin is between about 50 to about 1000 units. 
   
   
       6 . The method of  claim 1 , wherein the pain associated with muscle spasms secondary to stroke are associated with muscle activity or contracture. 
   
   
       7 . The method of  claim 1 , wherein administration of botulinum toxin does not cause local hypotonicity to develop. 
   
   
       8 . The method of  claim 1 , wherein administration of botulinum toxin is to major muscles involved in severe closing of the patient's hand. 
   
   
       9 . The method of  claim 1 , wherein administration of botulinum toxin is to muscles involved in curling of the patient's wrist. 
   
   
       10 . The method of  claim 1 , wherein administration of botulinum toxin is to muscles involved in closing of the patient's legs. 
   
   
       11 . The method of  claim 1 , wherein administration of botulinum toxin treats pain associated with muscle spasms secondary to stroke in seven to twenty-one days after administration. 
   
   
       12 . A method for treating pain associated with muscle spasms secondary to stroke in a patient in need thereof, the method comprising the step of administering from 50 to 300 units of a botulinum toxin type A to muscles of the patient having muscle spasms secondary to stroke, thereby treating pain associated with muscle spasms secondary to stroke. 
   
   
       13 . The method of  claim 12 , wherein administration of botulinum toxin is to major muscles involved in severe closing of the patient's hand. 
   
   
       14 . The method of  claim 12 , wherein administration of botulinum toxin is to muscles involved in curling of the patient's wrist. 
   
   
       15 . The method of  claim 12 , wherein administration of botulinum toxin is to muscles involved in closing of the patient's legs. 
   
   
       16 . The method of  claim 12 , wherein administration of botulinum toxin does not cause local hypotonicity to develop. 
   
   
       17 . A method for treating pain associated with muscle spasms secondary to stroke in a patient in need thereof, the method comprising the step of administering from 0.01 to 460 units of a botulinum toxin type A to muscles of the patient having muscle spasms secondary to stroke, whereby extensive local hypotonicity does not result and thereby treating pain associated with muscle spasms secondary to stroke. 
   
   
       18 . The method of  claim 17 , wherein administration of botulinum toxin is to major muscles involved in severe closing of the patient's hand. 
   
   
       19 . The method of  claim 17 , wherein administration of botulinum toxin is to muscles involved in curling of the patient's wrist. 
   
   
       20 . The method of  claim 17 , wherein administration of botulinum toxin is to muscles involved in closing of the patient's legs.