Alpha-1d calcium channel expressed in atrium

Abstract

Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed.

1 .- 16 . (canceled) 
     
     
         17 . An isolated L-type calcium α 1D+KIVA  subunit nucleic acid molecule that encodes a polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:4, and wherein the Polypeptide comprises the following features: (a) a deletion of amino acids 1291-1305 of SEQ ID NO:6; (b) an insertion of SEQ ID NO:2; and (c) a deletion of amino acids 1804-1812 of SEQ ID NO:6. 
     
     
         18 . The nucleic acid molecule of  claim 17 , wherein the nucleic acid comprises the nucleotide sequence of SEQ ID NO: 3. 
     
     
         19 . The nucleic acid molecule of  claim 18 , wherein the nucleic acid molecule consists of the nucleotide sequence of SEQ ID NO: 3. 
     
     
         20 . The nucleic acid molecule of  claim 17 , wherein the nucleic acid is an allele of the nucleic acid sequence of SEQ ID NO: 3. 
     
     
         21 . A fragment of the L-type calcium α 1D+KIVA  subunit nucleic acid molecule of  claim 17 , wherein the fragment encodes SEQ ID NO: 2. 
     
     
         22 . An expression vector comprising the L-type calcium α 1D+KIVA  subunit nucleic acid molecule of  claim 17  operably linked to a promoter. 
     
     
         23 . A host cell comprising the nucleic acid of  claim 17 . 
     
     
         24 .- 58 . (canceled) 
     
     
         59 . The nucleic acid molecule of  claim 17 , wherein the polypeptide comprises an amino acid sequence of SEQ ID NO:4. 
     
     
         60 . The nucleic acid molecule of  claim 17 , wherein the polypeptide consists of an amino acid sequence of SEQ ID NO:4.