US2009124832A1PendingUtilityA1
Oligoamine compounds and derivatives thereof for cancer therapy
Assignee: PROGEN PHARMACEUTICALS INCPriority: Oct 16, 2001Filed: Jan 21, 2009Published: May 14, 2009
Est. expiryOct 16, 2021(expired)· nominal 20-yr term from priority
Inventors:Benjamin FrydmanLinda CliffordAldonia ValasinasAndrei V. BlokhinHirak S. BasuLaurence J. MartonVenodhar K. Reddy
C07C 215/18C07C 211/14A61P 35/00
60
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Claims
Abstract
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
Claims
exact text as granted — not AI-modified1 . A compound of the formula
where R 10 , R 20 , R 60 , and R 70 are independently selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, and t-butyl;
each R 80 and R 90 are independently selected from H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, and t-butyl;
R 30 , each R 40 , and R 50 are independently selected from.
—CH 2 CH 2 CH 2 CH 2 —
—CHOHCH 2 CH 2 CH 2 —
—CH 2 CHOHCH 2 CH 2 —
—CH 2 CH 2 CHOHCH 2 —
—CH 2 CH 2 CH 2 CHOH—
—CH 2 CH 2 CH 2 —
—CHOHCH 2 CH 2 —
—CH 2 CHOHCH 2 — and
—CH 2 CH 2 CHOH—;
and where y is an integer selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13;
and all salts thereof
2 . A compound according to claim 1 , where each R 40 is independently selected from the group consisting of —CH 2 CH 2 CH 2 — and —CH 2 CH 2 CH 2 CH 2 —.
3 . A compound according to claim 2 , where each R 40 is —CH 2 CH 2 CH 2 CH 2 —.
4 . A compound according to claim 3 , where R 30 and R 50 are —CH 2 CH 2 CH 2 CH 2 —.
5 . A compound according to claim 4 , where R 90 and each R 80 are H.
6 . A compound according to claim 5 , where R 10 is H, R 20 is ethyl, R 60 is H, and R 70 is ethyl.
7 . A compound according to claim 6 , where y is an integer selected from 5, 7, 9, 11, and 13.
8 . A compound according to claim 7 , where y is an integer selected from 5, 9, and 11.
9 . A compound according to claim 1 of the formula
and all salts thereof.
10 . A compound according to claim 1 of the formula
and all salts thereof.
11 . A compound according to claim 1 of the formula
and all salts thereof
12 . A compound according to claim 1 of the formula
and all salts thereof.
13 . A compound according to claim 1 , where R 90 and each R 80 are independently selected from the group consisting of H, methyl, and ethyl.
14 . A compound according to claim 1 , where R 90 and each R 80 are H.
15 . A compound according to claim 1 , where R 30 , each R 40 , and R 50 are independently selected from:
—CH 2 CH 2 CH 2 CH 2 —
—CHOHCH 2 CH 2 CH 2 —
—CH 2 CHOHCH 2 CH 2 —
—CH 2 CH 2 CHOHCH 2 —, and
—CH 2 CH 2 CH 2 CHOH—.
16 . A compound according to claim 11 , where each R 40 is —CH 2 CH 2 CH 2 CH 2 — and R 30 and R 50 are independently selected from:
—CH 2 CH 2 CH 2 CH 2 —
—CHOHCH 2 CH 2 CH 2 —
—CH 2 CHOHCH 2 CH 2 —
—CH 2 CH 2 CHOHCH 2 —, and
—CH 2 CH 2 CH 2 CHOH—.
17 . A compound according to claim 16 , where R 30 and R 50 are independently selected from:
—CHOHCH 2 CH 2 CH 2 —
—CH 2 CHOHCH 2 CH 2 —
—CH 2 CH 2 CHOHCH 2 —, and
—CH 2 CH 2 CH 2 CHOH—.
18 . A compound according to claim 1 , where R 10 , R 20 , R 60 , and R 70 are independently selected from H, methyl, or ethyl.
19 . A compound according to claim 18 , where R 10 is H and R 60 is H.
20 . A compound according to claim 19 , where R 20 and R 70 are ethyl.
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