External preparation for skin

Abstract

The present invention provides an external preparation for skin which contains 5-aminolevulinic acids as active components and which is excellent in skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum; and in an ameliorating effect on skin diseases such as atopic dermatitis. An external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components, is used.

1 . An external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       2 . The external preparation for skin according to  claim 1 , which further contains urea as an active component. 
   
   
       3 . The external preparation for skin according to  claim 1  or  2 , wherein the iron compound is one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate. 
   
   
       4 . A preventive/ameliorating drug for skin roughness which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       5 . The preventive/ameliorating drug for skin roughness according to  claim 4 , wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate, are used as an iron compound. 
   
   
       6 . A preventive/ameliorating drug for dry skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       7 . The preventive/ameliorating drug for dry skin according to  claim 6 , wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate, are used as an iron compound. 
   
   
       8 . A preventive/ameliorating drug for wrinkles/flecks which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       9 . The preventive/ameliorating drug for wrinkles/flecks according to  claim 8 , wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate, are used as an iron compound. 
   
   
       10 . A method for preventing/ameliorating skin roughness comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       11 . A method for preventing/ameliorating dry skin comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       12 . A method for preventing/ameliorating wrinkles/flecks comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       13 . An ameliorating drug for atopic dermatitis which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       14 . The ameliorating drug for atopic dermatitis according to  claim 13 , wherein one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate, are used as an iron compound. 
   
   
       15 . A method for ameliorating atopic dermatitis comprising administering transdermally an external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components. 
   
   
       16 . A set of external preparations for skin consisting of a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound. 
   
   
       17 . The set of external preparations for skin according to  claim 16 , wherein the first agent and/or the second agent further contain urea. 
   
   
       18 . The set of external preparations for skin according to  claim 16  or  17 , wherein the iron compound is one or more compounds selected from the group consisting of ferrous citrate, iron sodium citrate, iron ammonium citrate, iron acetate, iron oxalate, ferrous succinate, iron and sodium succinate citrate, ferrous pyrophosphate, ferric pyrophosphate, heme iron, iron dextran, iron lactate, ferrous gluconate, iron sodium diethylenetriaminepentaacetate, iron ammonium diethylenetriaminepentaacetate, iron sodium ethylenediaminetetraacetate, iron ammonium ethylenediaminepentaacetate, iron triethylenetetraamine, iron sodium dicarboxymethylglutamate, and iron ammonium dicarboxymethylglutamate. 
   
   
       19 . A method for preventing/ameliorating skin roughness comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound. 
   
   
       20 . A method for preventing/ameliorating dry skin comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound. 
   
   
       21 . A method for preventing/ameliorating wrinkles/flecks comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound. 
   
   
       22 . A method for ameliorating atopic dermatitis comprising administering transdermally a first agent which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them, and a second agent which contains an iron compound.