Absorbable implantable vaso-occlusive member

Abstract

Compositions comprising absorbable implantable vaso-occlusive members are described. Also described are methods of making and using these absorbable vaso-occlusive compositions.

1 . A vaso-occlusive member comprising a completely absorbable vaso-occlusive device having a three-dimensional configuration. 
     
     
         2 . The vaso-occlusive member of  claim 1  further comprising a stretch-resistant member fixedly attached to at least two locations of the absorbable vaso-occlusive device. 
     
     
         3 . The vaso-occlusive member of  claim 2 , wherein the absorbable device is configured as a helical coil having a plurality of helical winds, a first end, a second end and lumen between said first and second ends. 
     
     
         4 . The vaso-occlusive member of  claim 3 , wherein the stretch-resistant member extends through said lumen of the coil and is attached to said first and second ends. 
     
     
         5 . The vaso-occlusive member of  claim 3 , wherein the stretch-resistant member is threaded through the winds of said coil. 
     
     
         6 . The vaso-occlusive member of  claim 3 , wherein the stretch-resistant member is attached to the interior or exterior of the helical coil. 
     
     
         7 . The vaso-occlusive member of  claim 2 , wherein the absorbable vaso-occlusive device comprises a tube. 
     
     
         8 . The vaso-occlusive member of  claim 7 , wherein the tube comprises a plurality of perforations therein. 
     
     
         9 . The vaso-occlusive member of  claim 8 , wherein the stretch-resistant member is threaded through at least two of said perforations. 
     
     
         10 . The vaso-occlusive member of  claim 7 , wherein the stretch-resistant member is attached to the interior or exterior of the tube. 
     
     
         11 . The vaso-occlusive member of  claim 2 , wherein the stretch-resistant member is absorbable. 
     
     
         12 . The vaso-occlusive member of  claim 2 , wherein the stretch-resistant member is non-absorbable. 
     
     
         13 . The vaso-occlusive member of  claim 11 , wherein the stretch-resistant member is formed by modifying the absorbable vaso-occlusive device. 
     
     
         14 . The vaso-occlusive device of  claim 13 , wherein the absorbable vaso-occlusive device is modified by heating or soldering at selected locations. 
     
     
         15 . The vaso-occlusive device of  claim 14 , wherein the absorbable vaso-occlusive device is shaped as a helical coil comprising a plurality of helical winds and wherein the heating or soldering serves to connect at least two of said helical winds. 
     
     
         16 . The vaso-occlusive device of  claim 14 , wherein the absorbable vaso-occlusive device is shaped as a tube and wherein the heating or soldering is at one or more positions on the exterior or interior of the tube. 
     
     
         17 . The vaso-occlusive member of  claim 1 , wherein the absorbable vaso-occlusive device comprises a material selected from the group consisting of polyglygolic acid (PGA), poly-glycolic/poly-L-lactic acid co-polymers, polycaprolactone, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide, polydioxanone, polycarbonates, polyanhydrides, collagen, elastin, fibrinogen, fibronectin, vitronectin, laminin, gelatin and combinations thereof. 
     
     
         18 . The vaso-occlusive member of  claim 2 , wherein the stretch-resistant member is a mono-filament. 
     
     
         19 . The vaso-occlusive member of  claim 18 , wherein the mono-filament comprises polypropylene. 
     
     
         20 . The vaso-occlusive member of  claim 2 , wherein the stretch-resistant member is a multi-filament. 
     
     
         21 . The vaso-occlusive member of  claim 1 , further comprising a deployment tip. 
     
     
         22 . The vaso-occlusive member of  claim 21 , wherein the deployment tip comprises an electrolytically detachable end adapted to detach from a pusher by imposition of a current on said pusher. 
     
     
         23 . The vaso-occlusive member of  claim 2 , further comprising a radio-opaque material. 
     
     
         24 . The method of  claim 23 , where the radio-opaque material is selected from the group consisting of powdered tantalum, powdered tungsten, bismuth oxide, and barium sulfate. 
     
     
         25 . The vaso-occlusive member of  claim 1 , further comprising a bioactive material.