Stabilization and ionic triggering of nitric oxide release

Abstract

Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a Ph adjuster with a diazeniumdiolate-containing compound or composition.

1 . A method for producing nitric oxide comprising:
 producing nitric oxide by using an ionic exchange resin.   
     
     
         2 . The method of  claim 1 , wherein the ionic exchange resin is an anionic exchange resin. 
     
     
         3 . The method of  claim 2 , wherein the anionic exchange resin has a counter ion selected from the group consisting of ascorbate, nitrite, a weak-acid anion, lactate, and a diazeniumdiolate-containing composition. 
     
     
         4 . The method of  claim 1 , wherein the ionic exchange resin is a cationic exchange resin. 
     
     
         5 . The method of  claim 4 , wherein the cationic exchange resin has a hydrogen-atom counter ion. 
     
     
         6 . The method of  claim 1 , wherein the ionic exchange resin is in a gel or cream. 
     
     
         7 . A method for producing nitric oxide comprising the step:
 mixing a salt with a cream, gel, or combination thereof to produce nitric oxide.   
     
     
         8 . The method of  claim 7 , wherein the salt is sodium chloride, sodium phosphate, or sodium acetate. 
     
     
         9 . The method of  claim 7 , wherein the cream or gel is an ion-free hydrogel, an off-white-oil-in-water vanishing cream, or a combination thereof. 
     
     
         10 . The method of  claim 7 , wherein the cream or gel has an ionic exchange resin therein. 
     
     
         11 . The method of  claim 10 , wherein the ionic exchange resin is an anionic exchange resin. 
     
     
         12 . The method of  claim 11 , wherein the anionic exchange resin has a counter ion selected from the group consisting of ascorbate, nitrite, a weak acid anion, lactate, and a diazeniumdiolate-containing composition. 
     
     
         13 . The method of  claim 10 , wherein the ionic exchange resin is an cationic exchange resin. 
     
     
         14 . The method of  claim 13 , wherein the cationic exchange resin has a hydrogen atom counter ion. 
     
     
         15 . The method of  claim 12 , further comprising reacting a hydrogen-atom cation with the ascorbate to produce ascorbic acid. 
     
     
         16 . The method of  claim 12 , further comprising reacting ascorbic acid with the nitrite to form nitric oxide. 
     
     
         17 . The method of  claim 12 , further comprising reacting a hydrogen cation with the diazeniumdiolate-containing composition to produce nitric oxide. 
     
     
         18 . A method for producing nitric oxide comprising the step:
 producing nitric oxide by adding a Ph adjuster to a nanofiber having a diazeniumdiolate functional group.   
     
     
         19 . The method of  claim 18 , wherein the nanofiber is a linear polyethylenimine fiber. 
     
     
         20 . The method of  claim 18 , wherein the nanofiber is an electrospun nanofiber. 
     
     
         21 . The method of  claim 18 , wherein the Ph adjuster is phosphate, lactate, citrate, or a combination thereof. 
     
     
         22 . A method for producing nitric oxide comprising the step:
 producing nitric oxide by adding a Ph adjuster to a nanoparticle having a diazeniumdiolate functional group.   
     
     
         23 . The method of  claim 22 , wherein the nanoparticle is cellulose, polystyrene, cm cellulose, or chitosan. 
     
     
         24 . The method of  claim 22 , wherein the Ph adjuster is phosphate, lactate, citrate, or a combination thereof. 
     
     
         25 . The method of  claim 22 , wherein the nanoparticle is within or attached to an electrospun nanofiber.