US2009137759A1PendingUtilityA1

Biochemical synthesis of 6-amino caproic acid

Assignee: DSM IP ASSETS BVPriority: Jan 19, 2004Filed: Jan 8, 2009Published: May 28, 2009
Est. expiryJan 19, 2024(expired)· nominal 20-yr term from priority
C12P 13/005C07D 223/10C12P 13/02C12N 9/001
53
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Claims

Abstract

The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.

Claims

exact text as granted — not AI-modified
1 - 23 . (canceled) 
     
     
         24 . Biochemically produced 6-aminohex-2-enoic acid, having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide. 
     
     
         25 . Biochemically produced 6-amino-hexanoic acid having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide. 
     
     
         26 . ε-Caprolactam produced from biochemically produced 6-aminohex-2-enoic acid or 6-amino-hexanoic acid, and having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide. 
     
     
         27 . Nylon-6 and other derivatives produced from the biochemically produced product of  claim 24 , and having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide. 
     
     
         28 . Nylon-6 and other derivatives produced from the biochemically produced product of  claim 25 , and having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide. 
     
     
         29 . Nylon-6 and other derivatives produced from ε-caprolactam according to  claim 26 , and having a  12 C versus  13 C versus  14 C isotope ratio of about the same value as occurring in environmental carbon dioxide.

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