Substituted azetidinones

Abstract

Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

1 . A compound described herein. 
   
   
       2 . A pharmaceutical composition comprising an effective amount of a compound described herein. 
   
   
       3 . A method for treating a disease comprising administering a therapeutically effective amount of a compound described herein. 
   
   
       4 . A method of inhibiting an enzyme in a mammal by administration of a compound described herein. 
   
   
       5 . A method of enhancing thrombolysis or treating thrombosis in a mammalian species comprising administering an effective amount of the composition of a compound described herein.