Bioactive coating for medical devices

Abstract

A medical device (and method for making same) comprising a passivating coating comprising keratin.

1 .- 33 . (canceled) 
     
     
         34 . A medical implant comprising:
 a substrate comprising a passivating coating comprising keratin, said passivating coating being effective to increase bone matrix formation by cultured 2T3 mouse osteoblasts, said passivating coating comprising a bonding region and a bioactive region;   said bonding region comprising at least one organosilane compound comprising a silane component bound to a surface of said substrate; and   said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.   
     
     
         35 . The medical implant of  claim 34  wherein said silane component of said organosilane compound is covalently bonded with a surface of the substrate. 
     
     
         36 . The medical implant of  claim 34  wherein said bioactive region comprises reactive pendant groups on said keratin covalently bonded to said organic component of said organosilane. 
     
     
         37 . (canceled) 
     
     
         38 . The medical implant of  claim 34  wherein said passivating coating comprises keratin and one or more bioactive factors selected from bone morphogenetic protein and transforming growth factor beta. 
     
     
         39 - 41 . (canceled) 
     
     
         42 . The medical implant of  claim 34  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups. 
     
     
         43 . (canceled) 
     
     
         44 . The medical implant of  claim 42  wherein said amine groups are alkylamine groups. 
     
     
         45 . The medical implant of  claim 34  wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups. 
     
     
         46 - 57 . (canceled) 
     
     
         58 . The medical implant of  claim 34  wherein said organosilane comprises substituents selected from 1 to 3 halogens and 1 to 3 alkoxy groups. 
     
     
         59 - 70 . (canceled) 
     
     
         71 . The medical implant of  claim 34  wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa. 
     
     
         72 - 160 . (canceled) 
     
     
         161 . A medical implant comprising:
 a substrate comprising a passivating coating comprising keratin, said passivating coating comprising a bonding region and a bioactive region;   said bonding region comprising at least one organosilane compound comprising a silane component bound to a surface of said substrate; and   said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.   
     
     
         162 . The medical implant of  claim 161  wherein said silane component of said organosilane compound is covalently bonded with a surface of the substrate. 
     
     
         163 . The medical implant of  claim 161  wherein said bioactive region comprises reactive pendant groups on said keratin covalently bonded to said organic component of said organosilane. 
     
     
         164 . (canceled) 
     
     
         165 . The medical implant of  claim 161  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups. 
     
     
         166 . (canceled) 
     
     
         167 . The medical implant of  claim 165  wherein said amine groups are alkylamine groups. 
     
     
         168 . The medical implant of  claim 161  wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups. 
     
     
         169 . The medical implant of  claim 163  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups. 
     
     
         170 . The medical implant of  claim 163  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, and amine groups. 
     
     
         171 . The medical implant of  claim 170  wherein said amine groups are alkylamine groups. 
     
     
         172 .- 176 . (canceled) 
     
     
         177 . The medical implant of  claim 161  wherein said organosilane comprises substituents are selected from 1 to 3 halogens and 1 to 3 alkoxy groups. 
     
     
         178 - 185 . (canceled) 
     
     
         186 . The medical implant of  claim 161  wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa. 
     
     
         187 - 199 . (canceled) 
     
     
         200 . The medical implant of  claim 161  wherein the substrate comprises one or more biocompatible material is selected from the group consisting of silicon, metals, metal alloys, and ceramics. 
     
     
         201 . The medical implant of  claim 161  wherein said biocompatible material is selected from the group consisting of titanium and hydroxyapatite. 
     
     
         202 . The medical implant of  claim 161  wherein said biocompatible material comprises silicon. 
     
     
         203 - 220 . (canceled) 
     
     
         221 . An orthopedic medical implant comprising:
 a substrate comprising a passivating coating comprising keratin, said passivating coating comprising a bonding region and a bioactive region;   said bonding region comprising at least one organosilane compound comprising a silane component covalently bound to a surface of said substrate; and   said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.   
     
     
         222 . The orthopedic implant of  claim 221  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups. 
     
     
         223 . The orthopedic implant of  claim 222  wherein said amine groups are alkylamine groups. 
     
     
         224 . The orthopedic implant of  claim 221  wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups. 
     
     
         225 . The medical implant of  claim 221  wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, and amine groups. 
     
     
         226 . The medical implant of  claim 227  wherein said amine groups are alkylamine groups. 
     
     
         227 . The medical implant of  claim 221  wherein said organosilane comprises substituents are selected from 1 to 3 halogens and 1 to 3 alkoxy groups. 
     
     
         228 . The medical implant of  claim 221  wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa. 
     
     
         229 . The medical implant of  claim 221  wherein the substrate comprises one or more biocompatible material is selected from the group consisting of silicon, metals, metal alloys, and ceramics. 
     
     
         230 . The medical implant of  claim 221  wherein said biocompatible material is selected from the group consisting of titanium and hydroxyapatite. 
     
     
         231 . The medical implant of  claim 221  wherein said biocompatible material comprises silicon.