Novel antimicrobial bolisin peptides

Abstract

The invention relates to antibiotically effective peptides which are prepared for medical and commercial use by using biotechnological methods and chemical synthesis. The antibiotically effective peptides can be used in a suitable galenic formulation as medicaments/animal medicaments, food additives or as preservatives for the prevention of microbial contaminations of cosmetics, medical products and requisites.

1 - 19 . (canceled) 
     
     
         20 : Artificial peptide selected from the group consisting of SEQ ID NOS: 1-42 and 44-56. 
     
     
         21 : The peptide of  claim 20  conjugated with a polymer. 
     
     
         22 : The peptide of  claim 20  conjugated with polysorbate. 
     
     
         23 : A medicament comprising an antibiotically effective amount of the peptide of  claim 20  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         24 : A medicament comprising an antibiotically effective amount of the peptide of  claim 21  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         25 : A medicament comprising an antibiotically effective amount of the peptide of  claim 22  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         26 : The medicament according to  claim 23  further comprising at least one ingredient, wherein the at least one ingredient is (i) an additional antibiotically effective ingredient (ii) an antivirally effective ingredient, an antiparasitically effective ingredient, or an antifungally effective ingredient. 
     
     
         27 : The medicament according to  claim 23  in an application form selected from the group consisting of an infusion, ointment, tablet, spray, and slow release capsule. 
     
     
         28 : The medicament according to  claim 24  in an application form selected from the group consisting of an infusion, ointment, tablet, spray, and slow release capsule. 
     
     
         29 : A diagnostic agent comprising an effective amount of the peptide of  claim 20  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         30 : A diagnostic agent comprising an effective amount of the peptide of  claim 21  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         31 : A diagnostic agent comprising an effective amount of the peptide of  claim 22  in combination with a pharmacologically acceptable carrier or diluent. 
     
     
         32 : A foodstuff incorporating the peptide of  claim 20 . 
     
     
         33 : A method for inhibiting the growth of a microorganism comprising contacting the microorganism with an antimicrobially effective amount of the peptide of  claim 20 . 
     
     
         34 : A method for inhibiting the growth of a microorganism comprising contacting the microorganism with an antimicrobially effective amount of the peptide of  claim 21 . 
     
     
         35 : A method for inhibiting the growth of a microorganism comprising contacting the microorganism with an antimicrobially effective amount of the peptide of  claim 22 . 
     
     
         36 : A process for preparing the peptide according to  claim 20  comprising expressing the protein in a prokaryotic or eukaryotic organism or chemically synthesizing the protein. 
     
     
         37 : A method of using the peptide of  claim 20  comprising administering an antimicrobially effective amount of the peptide to a patient in need thereof.