Tricyclic steroid hormone nuclear receptor modulators

Abstract

The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.

1 - 121 . (canceled) 
   
   
       122 . A method for the treatment of diastolic or systolic congestive heart failure comprising administering to a patient in need thereof an effective amount of a compound of Formula I: 
     
       
         
         
             
             
         
       
     
     wherein,
 “A” represents 
 
     
       
         
         
             
             
         
       
       “B” represents 
     
     
       
         
         
             
             
         
       
       
         represents: 
       
     
     
       
         
         
             
             
         
       
       X and Y together represent —CH 2  CH 2 —, —CH 2 —O—, or —OH 2 —; 
          represents a double bond; 
       R 4 -R 7  each independently represent hydrogen, hydroxy, halo, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkoxy; and 
       R 8  represents hydrogen or (C 1 -C 6 )alkyl; 
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       123 . The method according to  claim 122  comprising administering to a patient in need thereof a compound of the formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       124 . A method for the treatment of hypertension comprising administering to a patient in need thereof an effective amount of a compound of Formula J: 
     
       
         
         
             
             
         
       
     
     wherein,
 “A” represents 
 
     
       
         
         
             
             
         
       
       “B” represents 
     
     
       
         
         
             
             
         
       
       
         represents: 
       
     
     
       
         
         
             
             
         
       
       X and Y together represent —CH 2  CH 2 —, —CH 2 —O—, or —OH 2 —; 
          represents a double bond; 
       R 4 -R 7  each independently represent hydrogen, hydroxy, halo, (C 1 -C 6 )alkyl, or (C 1 -C 6 )alkoxy; and 
       R 8  represents hydrogen or (C 1 -C 6 )alkyl; 
     
     or a pharmaceutically acceptable salt thereof. 
   
   
       125 . The method according to  claim 124  comprising administering to a patient in need thereof a compound of the formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable salt thereof.