Proteins in type 2 diabetes

Abstract

The present invention relates to the use of naturally occurring compounds and derivatives thereof as markers for predisposition of diabetes related diseases. The invention also relates to a pharmaceutical composition for treatment of diabetes related diseases.

1 . A test kit for diagnosing a diabetes-related disease or a predisposition, e.g. genetic, for said disease in a mammal, said test kit comprising:
 (A) at least one binding means which specifically binds to at least one marker protein chosen from the group consisting of:   (a) ATP synthase beta subunit or phosphorylated ATP synthase beta subunit isoforms;   (b) phosphoglucomutase 1;   (c) heat shock protein 90 beta;   (d) creatine kinase B subunit;   (e) myosin regulatory light chain 2;   (f) collagen alpha1 (VI) chain;   (g) 78 kDa glucose-regulated protein;   (h) a marker protein defined by the characteristics disclosed in table 3 (match nos: 199, 303, 391, or 511);   (B) at least one means for detecting binding, if any, or the level of binding, of a binding means to at least one of said marker proteins; and, if necessary,   (C) at least one means for correlating whether binding, if any, or the level of binding, to said binding means is indicative of the individual mammal having a significantly higher likelihood of having the disease or a (genetic) predisposition for having the disease.   
     
     
         2 . A test kit according to  claim 1 , wherein the at least one marker protein is 1, 2, 3, 4, 5, 6 or more marker proteins. 
     
     
         3 . A test kit according to  claim 1 , wherein the at least one marker protein is 2 marker proteins. 
     
     
         4 . A test kit according to  claim 1 , wherein the at least one marker protein is 3 marker proteins. 
     
     
         5 . A test kit according to  claim 1 , wherein the at least one marker protein is 4 marker proteins. 
     
     
         6 . A test kit according to  claim 1 , wherein the at least one marker protein is 5 marker proteins. 
     
     
         7 . A test kit according to  claim 1 , wherein the at least one marker protein is 6 marker proteins.