Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins

Abstract

Heat treated bacterins, a method of producing heat treated bacterins, and porcine emulsion vaccines prepared from such heat treated bacterins are disclosed.

1 . A vaccine comprising an emulsion, a heat treated bacterin comprising a suspension of killed bacteria, wherein the killed bacteria are of the species  Leptospira Bratislava  and 1 to 13 porcine disease causing viruses selected from the group consisting of Porcine Adenovirus, Porcine Circovirus, Porcine herpes viruses, Pseudorabies virus, Classical swine fever virus, Porcine epidemic diarrhea virus, Porcine hemaglutinating encephalomyelitis virus, Porcine parvovirus, Porcine Respiratory Corona virus, Porcine Reproductive and Respiratory Virus, Swine Influenza, Transmissible gastroenteritis virus, and Vesicular stomatitis virus. 
   
   
       2 . A vaccine according to  claim 1  further comprising a lecithin preparation, and alum based adjuvant. 
   
   
       3 . A vaccine according to  claim 2  further comprising a lecithin in oil preparation. 
   
   
       4 . A vaccine according to  claim 1  further comprising heat treated bacterins comprising a suspension of killed bacteria, wherein the killed bacteria are one to six bacteria species selected from the group consisting of  Leptospira canicola, Leptospira icterohaemorrhagiae, Leptospira  grippotyphosa,  Leptospira hardjo, Leptospira Pomona , and  Erysipelothrix rhusiopathieae.    
   
   
       5 . A vaccine according to  claim 4  further comprising a lecithin preparation, and alum based adjuvant. 
   
   
       6 . A vaccine according to  claim 5  further comprising a lecithin in oil preparation.