Anti-Inflammatory Agent and Cancer-Preventive Agent Comprising Canolol or Prodrug Thereof and Pharmaceutical, Cosmetic and Food Comprising the Same

Abstract

An anti-inflammatory agent or cancer-preventive agent comprising 4-vinyl-2,6-dimethoxyphenol of the formula (1): or a PD thereof.

1 : An anti-inflammatory agent or cancer-preventive agent comprising 4-vinyl-2,6-dimethoxyphenol 
     
       
         
         
             
             
         
       
     
     or prodrug thereof. 
   
   
       2 : The anti-inflammatory agent according to  claim 1  for treatment of one or more diseases selected from the group consisting of gastro-duodenitis, gastro-duodenal ulcer, gastritis, bronchitis, rheumatism, hepatitis, colitis, conjunctivitis, pneumonitis, pancreatitis, stomatitis, pharyngitis and burn. 
   
   
       3 : The anti-inflammatory agent according to  claim 1 , wherein inflammation is suppressed by suppression of 8-oxodeoxyguanosine formation, inhibition of COX-2 activity, inhibition of iNOS activity, suppression of NO production inhibition of cytokine induction or any combination thereof. 
   
   
       4 : The cancer-preventive agent according to  claim 1 , wherein carcinogenesis is prevented by suppression of mutagenesis by peroxynitrite. 
   
   
       5 : The anti-inflammatory agent or cancer-preventive agent according to  claim 1 , further comprising an excipient for medicament. 
   
   
       6 : The anti-inflammatory agent or cancer-preventive agent according to  claim 1 , further comprising a cosmetic ingredient. 
   
   
       7 : The anti-inflammatory agent or cancer-preventive agent according to  claim 6  for treatment of one or more symptoms of aging of skin, cytotoxicity and sun burn. 
   
   
       8 : The anti-inflammatory agent or cancer-preventive agent according to  claim 1  in the form of a cream, tablet, capsule, lipid formulation, aqueous formulation (water solubilized form) or emulsion. 
   
   
       9 : The anti-inflammatory agent or cancer-preventive agent according to  claim 1 , further comprising a food ingredient.