Iron-salen complex

Abstract

The present invention provides a drug delivery system that overcomes conventional technical problems and that is readily put to practical use. Iron-salen complexes represented by General Formula (I) below. The invention renders iron-salen complexes magnetic, which can thus be used as drugs that can be delivered to affected areas in the body using the inherent magnetic properties of the drug without employing carriers composed of magnetic substances as has been done hitherto.

1 . An iron-salen complex represented by any of the following Formulas (I) to (V): 
       
         
           
           
               
               
           
         
         (where X is any of the following: 
         —H 
         —CO 2 M e    
         —CO(OCH 2 CH 2 ) n OCH 3    
       
       
         
           
           
               
               
           
         
         (where R 2  comprises a plurality of bound nucleic acids selected from the group consisting of adenine, guanine, thymine, cytosine, or uracil) or 
         —NHR 1  (where R 1  is a substituent with a hydroxyl, a substituted hydroxyl, an ester, or a carbonyl) 
       
       
         
           
           
               
               
           
         
         (where X is —NHR 1  (where R 1  is a substituent with a hydroxyl, a substituted hydroxyl, an ester, or a carbonyl), —Cl, —Br, or —H) 
       
       
         
           
           
               
               
           
         
         (where Y is —H, —NH 2 , or —NHR 1  (where R 1  is a substituent with a hydroxyl, a substituted hydroxyl, an ester, or a carbonyl), and Z is —Cl or —NHR 1  (where R 1  is a substituent with a hydroxyl, a substituted hydroxyl, an ester, or a carbonyl)) 
       
       
         
           
           
               
               
           
         
         (where R 1  is —Cl or —NHR 1  (where R 1  is a substituent with a hydroxyl), and R 2  is —H, —NH 2 , or —NHR 1  (where R 1  is a substituent with a hydroxyl, a substituted hydroxyl, an ester, or a carbonyl)). 
       
     
     
         2 . The iron-salen complex according to  claim 1 , wherein the charge transfer of R 1  is less than 0.5 electrons (e). 
     
     
         3 . The iron-salen complex according to  claim 1 , wherein R 1  is a substituent which is the result of a hydrogen or a hydroxyl leaving any of the compounds of the following Formulas (1) to (27): 
       
         
           
           
               
               
           
         
         (1): ibuprofen piconol, phenylpropionic acid analgesics/anti-inflammatories 
       
       
         
           
           
               
               
           
         
         (2): mefenamic acid, anthranilic acid antipyretic anti-inflammatory analgesics 
       
       
         
           
           
               
               
           
         
         (3) drugs for treating hyperlipemia 
       
       
         
           
           
               
               
           
         
         (4): antibacterials 
       
       
         
           
           
               
               
           
         
         (5): fluorochromes (rhodamines) 
       
       
         
           
           
               
               
           
         
         (6): hormones (estrogen) 
       
       
         
           
           
               
               
           
         
         (7): hormones (estrogen) 
       
       
         
           
           
               
               
           
         
         (8): Taxol (paclitaxel) 
       
       
         
           
           
               
               
           
         
         (9): amino acids (glycine) 
       
       
         
           
           
               
               
           
         
         (10): amino acids (alanine) 
       
       
         
           
           
               
               
           
         
         (11): amino acids (arginine) 
       
       
         
           
           
               
               
           
         
         (12): amino acids (asparagine) 
       
       
         
           
           
               
               
           
         
         (13): amino acids (aspartic acid) 
       
       
         
           
           
               
               
           
         
         (14) amino acids (cysteine) 
       
       
         
           
           
               
               
           
         
         (15): amino acids (glutamic acid) 
       
       
         
           
           
               
               
           
         
         (16): amino acids (histidine) 
       
       
         
           
           
               
               
           
         
         (17): amino acids (isoleucine) 
       
       
         
           
           
               
               
           
         
         (18): amino acids (leucine) 
       
       
         
           
           
               
               
           
         
         (19): amino acids (lysine) 
       
       
         
           
           
               
               
           
         
         (20): amino acids (methionine) 
       
       
         
           
           
               
               
           
         
         (21) amino acids (phenylalanine) 
       
       
         
           
           
               
               
           
         
         (22): amino acids (proline) 
       
       
         
           
           
               
               
           
         
         (23): amino acids (serine) 
       
       
         
           
           
               
               
           
         
         (24): amino acids (threonine) 
       
       
         
           
           
               
               
           
         
         (25) amino acids (tryptophan) 
       
       
         
           
           
               
               
           
         
         (26): amino acids (tyrosine) 
       
       
         
           
           
               
               
           
         
         (27): amino acids (valine). 
       
     
     
         4 . An iron-salen complex represented by the following formula: 
       
         
           
           
               
               
           
         
       
     
     
         5 . A magnetic drug, comprising an iron-salen complex according to  claim 1 . 
     
     
         6 . A method for diagnosing the human body with a magnetic drug, comprising an iron-salen complex according to  claim 1 . 
     
     
         7 . A method for treating the human body with a magnetic drug, comprising an iron-salen complex according to  claim 1 .