Method For Producing Amide Compound

Abstract

[Problems] The present invention provides a method for efficiently producing a corresponding amide compound from a nitrile compound by a reaction using a nitrile hydratase and a method for producing an amide-based polymer excellent in quality from the amide compound. In addition, the present invention provides a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between the water solubility and the high molecular weight and is also excellent in quality, by using the acrylamide. [Means for Solving the Problems] The method for producing an amide compound of the present invention is characterized in that in a method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity, the concentration of benzene in the aqueous medium is 4.0 ppm or less. In addition, the method for producing an amide-based polymer of the present invention is characterized by homopolymerizing the amide compound or by copolymerizing the amide compound and at least unsaturated monomer copolymerizable with the amide compound. Further, the method for producing acrylamide of the present invention is characterized by hydrating acrylonitrile having a concentration of acrolein of 1 ppm or less by a microbial cell containing a nitrile hydratase or a processed product of the microbial cell in an aqueous medium. Furthermore, the method for producing an acrylamide-based polymer of the present invention is characterized by homopolymerizing the acrylamide or by copolymerizing the acrylamide and at least one unsaturated monomer copolymerizable with the acrylamide.

1 . A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity, wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less. 
   
   
       2 . The method for producing an amide compound according to  claim 1 , wherein the nitrile hydratase is a nitrile hydratase derived from  Pseudonocardia  or derived from  Rhodococcus.    
   
   
       3 . The method for producing an amide compound according to  claim 1 , wherein the nitrile compound is acrylonitrile or methacrylonitrile. 
   
   
       4 . A method for producing an amide-based polymer, comprising homopolymerizing the amide compound according to  claim 1  or copolymerizing the amide compound and at least one unsaturated monomer copolymerizable with the amide compound. 
   
   
       5 . The method for producing an amide-based polymer according to  claim 4 , wherein the amide compound is acrylamide or methacrylamide. 
   
   
       6 . A method for producing an acrylamide, comprising hydrating an acrylonitrile having an acrolein concentration of 1 ppm or less by a microbial cell containing a nitrile hydratase or a processed product of the microbial cell in an aqueous medium. 
   
   
       7 . A method for producing an acrylamide-based polymer, comprising homopolymerizing the acrylamide according to  claim 6  or copolymerizing the acrylamide and at least one unsaturated monomer copolymerizable with the acrylamide. 
   
   
       8 . The method for producing an amide compound according to  claim 2 , wherein the nitrile compound is acrylonitrile or methacrylonitrile.