Clay-based hemostatic agents and devices for the delivery thereof

Abstract

A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

1 . A hemostatic product comprising:
 hemostatic device comprising:
 a substrate; and 
 a hemostatic agent disposed on or into said substrate; 
   wherein the substrate is folded into a pleated form; and   a package containing the hemostatic device;   wherein the hemostatic product is prepared by a process comprising applying a vacuum.   
     
     
         2 . The product of  claim 1 , wherein the substrate comprises gauze. 
     
     
         3 . The product of  claim 1 , wherein the hemostatic agent comprises at least one of: a bioactive glass, a biological hemostat, a molecular sieve, diatomaceous earth, a clay material, and chitosan. 
     
     
         4 . The product of  claim 3 , wherein the hemostatic agent comprises a clay material. 
     
     
         5 . The product of  claim 4 , wherein the clay material comprises at least one of attapulgite, bentonite, and kaolin. 
     
     
         6 . The product of  claim 5 , wherein the clay material comprises kaolin. 
     
     
         7 . The product of  claim 1 , further comprising a release agent disposed on the substrate. 
     
     
         8 . A device comprising:
 a substrate;   a hemostatic agent disposed on the substrate; and   a pharmaceutically active composition disposed on the substrate.   
     
     
         9 . The device of  claim 8 , wherein the pharmaceutically active composition comprises an analgesic or an anti-inflammatory agent. 
     
     
         10 . The device of  claim 9 , wherein the pharmaceutically active composition further comprises at least one of: an antibiotic, an antifungal agent, an anti-microbial agent, a silver ions, or copper ions. 
     
     
         11 . The device of  claim 8 , wherein the pharmaceutically active agent comprises an analgesic. 
     
     
         12 . The device of  claim 8 , wherein the pharmaceutically active agent comprises an anti-inflammatory agent. 
     
     
         13 . The device of  claim 9 , wherein the hemostatic agent comprises a clay. 
     
     
         14 . The device of  claim 13 , wherein the clay comprises kaolin.